Increasing societal dependence on manmade chemicals and lack of knowledge about their potential adverse effects is a major threat to wildlife and human health. Evidence show that exposure to air pollution or the over 100,000 chemicals that contaminate our environment are main risk factors for many chronic diseases. Understanding what environmental contaminants we are exposed to, their properties and the interactions with biological systems are therefore essential.
There has been a rapidly increasing interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and thereby affect gene expression and phenotype in humans and wildlife. We aim to combine experimental model systems, omics tools and molecular epidemiological research to study Gene-Environment interactions and epigenetic basis of disease. In particular, our research focuses on developmental origins of health and disease with an emphasis on the exposome and underlying molecular mechanisms. The projects concern the effects of environmental exposures such as endocrine disrupting chemicals, flame retardants, pesticides, metals, particulate air pollution, temperature changes, as well as drugs, psycho-social stressors and ethnical disparities. Ongoing efforts include studies of paternal epigenetic inheritance.
Paula Pierozan, Post doc
Liselott Källsten, PhD student
Eleftheria Theodoropoulou, PhD student
Radwa Almamoun, PhD student
Daiane Cattani, Post doc