Drug Delivery group
We wish to understand drug properties at the molecular and cellular level in order to deliver drugs more effectively via the oral route. Our research program has provided insights into new mechanisms for drug absorption, disposition and delivery, and contributed to the development of new therapeutic strategies for efficient oral drug delivery. We are approximately 30 researchers/PhD /Master students working in three integrated groups, dealing with poorly soluble drugs, (contact Christel Bergström); In silico and in vitro predictions of drug delivery (contact Per Artursson) and Drug Optimization and Pharmaceutical Profiling (contact Pawel Baranczewski).
Our research has resulted in the national resource, Uppsala University Drug Optimization and Pharmaceutical Profiling (UDOPP), which advances academic and industrial discovery projects with physicochemical, absorption, distribution, metabolism and elimination (ADME) profiling of compound libraries. UDOPP is an integrated facility within the SciLifeLab platform for Drug Discovery and Development and is responsible for compound profiling within the innovative medicines project ENABLE (European Gram-negative Antibacterial Engine), that is working to advance the development of potential antibiotics against Gram-negative bacteria.
The Drug Delivery group takes a multidisciplinary approach and combines computational chemistry and bioinformatics with cell- and molecular biology, biopharmaceutics, pharmacokinetics, pharmaceutics and use of various omics technologies to find new ways to predict and define rate-limiting barriers to the absorption and organ distribution of different types of drugs and to characterize drug transport routes across organ barriers, in particular the intestine and liver.
Vildhede A., Wisniewski J.R., Norén A., Karlgren M., Artursson P. Comparative proteomic analysis of human liver tissue and isolated hepatocytes with a focus on proteins determining drug exposure. J Proteome Res. 2015, 14: 3305-14.
Alskär LC, Porter CJ, Bergström CA. Tools for Early Prediction of Drug Loading in Lipid-Based Formulations. Mol Pharm. 2016, 13:251-61
Almqvist, H., Axelsson, H., Jafari, R., Dan, C., Mateus, A., Haraldsson, M., Larsson, A., Artursson, P., Martinez-Molina, D., Nordlund, P. In cell CETSA screening identifies known and novel thymidylate synthase inhibitors and slow activation of 5-FU. Nat Commun. 2016, 7:11040
Over, B., Matsson, P., Tyrchan, C., Artursson, P., Doak, B., Foley, M., Hilgedorf, C., Johnston, S., Lee, M., Lewis, R., McCarren, P., Muncipinto, G., Perry,M., Duvall, J., Kihlberg, J. Structural and conformational determinants of macrocycle cell permeability. Nat Chem Biol, 12:1065-1074, 2016
Holmboe M, Larsson P, Anwar J, Bergström CA. Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations. Langmuir. 2016, 32(48):12732-12740