Per Ljungdahl portrait

Per O. Ljungdahl

Director Campus Solna, Stockholm University

Key publications

Jenull, S., Mair, T., Tscherner, M., Zwolanek, F., Silao, F.G.S., Martinez de San Vicente, K., Riedelberger, M., Bandari, N.C., Shivarathri, R., Petryshyn, A., Chauhan, N., Zacchi, L.F., LeibundGut-Landmann, S., Ljungdahl, P.O. and Kuchler, K. (2021)
The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.
Cell Rep. 36(3):109406. doi: 10.1016/j.celrep.2021.109406


Danko, D.*, Bezdan, D.* . . . Ljungdahl, P. . . .Mason, C.E., and The International MetaSUB Consortium. (2021)
Global genetic cartography of urban metagenomes and anti-microbial resistance.
Cell 184(13):3376-3393.e17. doi: 10.1016/j.cell.2021.05.002

Silao, F.G.S., Ryman, K., Jiang, T., Ward, M., Hansmann, N. Molenaar, C., Liu, N-.N. Chen, C. and Ljungdahl, P.O. (2020)
Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.
PLoS Pathogens 16(9): e1008328. doi: 10.1371/journal.ppat.1008328. Correction: PLoS Pathogens. (2021) 17(8):e1009877. doi:10.1371/journal.ppat.1009877

Silao, F.G.S., Ward, M., Ryman, K., Wallström, A. Brindefalk, B., Udekwu, K. and Ljungdahl, P.O. (2019)
Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans.
PLoS Genet 15(2): e1007976

Ring, A., Martins, A. and Ljungdahl, P.O. (2019)
Ssy1 functions at the plasma membrane as a receptor of extracellular amino acids independent of PM-ER junctions.
Traffic 20(10):775-784. doi: 10.1111/tra.12681

Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldívar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engström Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Köhler JR. (2018)
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
PLoS Pathog. 14(7):e1007076.

Per O. Ljungdahl

Professor in Cell Biology, Stockholm University University, Dept Molecular Biosciences, Wenner-Gren Institute

Metabolic and spatio-temporal determinants of fungal virulence

Humans are hosts to a wide range of commensal microorganisms. The microflora consists largely of prokaryotes, but eukaryotic fungi are also important with Candida spp. being dominant. Several Candida spp. are capable of causing life-threatening infections in immunocompromised individuals. Since the incidence of Candida infections is low in healthy populations, primary immune cells are key to restricting virulent growth. Candida albicans, the major cause of human mycoses, can switch morphologies from yeast-like to filamentous forms, a virulence property linked to macrophage escape and invasive growth through epithelial barriers. We recently identified proline catabolism as essential for inducing and supplying the energy for filamentous growth. Based on this new knowledge, we are pursuing three experimental aims. First, we are dissecting the metabolic control of proline-dependent virulence with a particular focus on mitochondria-localized processes critical for fungal cell survival. Second, using intra vital 2-photon microscopy we have visualized the spatio-temporal aspects of C. albicans infections in the kidney of a living mammalian host (mouse) and, currently in collaboration, are working to precisely define host-pathogen interactions by STED microscopy and spatio-transcriptomic analysis. Third, we are investigating proline catabolism in Candida auris, a new and significant global threat to human health.

Group Members

  • Fitz Gerald S Silao, senior researcher
  • Ioanna Myronidi, PhD student
  • Biborka Bereczky Veress, senior researcher

Last updated: 2022-11-30

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