Key publications

Pulkkinen LIA, Barrass SV, Lindgren M, Pace H, Överby AK, Anastasia M, Bally M, Lundmark R, Butcher SJ. Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein. PLOS pathogens, Feb 14;19(2):e1011125. doi: 10.1371/journal.ppat.1011125. PMID: 36787339, Co-corresponding senior author (2023)

Larsson E, Morén B, McMahon KA, Parton RG, Lundmark R; Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization. Journal of Cell Biology. Apr 3;222(4):e202205122. doi: 10.1083/jcb.202205122. PMID: 36729022 (2023)

Liu K-C, Pace H, Larsson E, Hossain S, Kabedev A, Shukla A, Jerschabek V, Mohan J, Bergström C AS, Bally M, Schwieger C, Hubert M and Lundmark R; Membrane insertion mechanism of the caveola coat protein Cavin1. Proceedings of the National Academy of Sciences, USA. Jun 21;119(25):e2202295119. doi: 10.1073/pnas.2202295119. PMID: 35696574 (2022)

Hubert M, Larsson E, Vegesna NVG, Ahnlund M, Johansson AI, Moodie LWK and Lundmark R; Lipid accumulation controls the balance between surface connection and scission of caveolae eLife. May 4;9:e55038. doi:10.7554/eLife.55038. (2020).

Yau WL, Nguyen-Dinh V, Larsson E, Lindqvist R, Överby AK, Lundmark R; Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication. Journal of Virology, Jun 26, JVI.00292-19. doi: 10.1128/JVI.00292-19, (2019)

Hoernke M, Mohan J, Larsson E, Blomberg J, Kahra D, Westenhoff S, Schwieger C, Lundmark R; EHD2 restrains dynamics of caveolae by an ATP dependent, membrane-bound, open conformation Proceedings of the National Academy of Sciences, USA,114(22), E4360-E4369 (2017).

We study proteins, lipids and mechanisms that are required to re-sculpture cellular membranes into highly curved vesicular structures, a necessity for trafficking, compartmentalization and balancing of the membrane integrity in cells. Membrane sculpting is fundamental for many cellular processes and malfunction is implicated in a broad range of human diseases. Furthermore, a large number of viruses induce vesicular membrane structures where the virus genome is replicated which is essential for infection of cells. Our group is focused on understanding the underlying mechanisms for the importance of membrane sculpting during infection, cancer, mental retardation, obesity, and muscle and lipid dystrophies.

We use a wide array of techniques ranging from protein and lipid biochemistry, mass spectrometry and structural analysis to advanced high speed imaging of molecules in living cells and correlative imaging approaches for ultra-structural resolution. Our work is focused on the mechanisms controlling the formation of the atypical membrane vesicles which are characteristically more stably attached to membranes as compared to previously described vesicles. Two examples of these atypical vesicles are caveolae, which are signalling platforms and regulators of lipid metabolism, and replication compartments induced by the tick borne encephalitis virus (TBEV). We study these model systems to understand the driving forces and role of the formation of stable membrane vesicles in cells.

Group members

Elin Larsson, PhD
Sebastian Rönfelt, PhD
Björn Morén, PhD
Wai Lok Yau, PhD
Lauri Pulkkinen, PhD

Last updated: 2023-04-06

Content Responsible: victor kuismin(