Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Päivi Östling, Olli P. Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtiö, Mattias Vesterlund, Rozbeh Jafari*. Nature Communications volume 13, Article number: 1691 (2022). https://doi.org/10.1038/s41467-022-29224-5
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.
Sophie A. Herbst*, Mattias Vesterlund*, Alexander J. Helmboldt, Rozbeh Jafari, Ioannis Siavelis, Matthias Stahl, Eva C. Schitter, Nora Liebers, Berit J. Brinkmann, Felix Czernilofsky, Tobias Roider, PeterMartin Bruch, Murat Iskar, Adam Kittai, Ying Huang, Junyan Lu, Sarah Richter, Georgios Mermelekas, Husen Muhammad Umer, Mareike Knoll, Carolin Kolb, Angela Lenze, Xiaofang Cao, Cecilia Österholm, Linus Wahnschaffe, Carmen Herling, Sebastian Scheinost, Matthias Ganzinger, Larry Mansouri, Katharina Kriegsmann, Mark Kriegsmann, Simon Anders, Marc Zapatka, Giovanni Del Poeta, Antonella Zucchetto, Riccardo Bomben, Valter Gattei, Peter Dreger, Jennifer Woyach, Marco Herling, Carsten MüllerTidow, Richard Rosenquist, Stephan Stilgenbauer, Thorsten Zenz, Wolfgang Huber, Eugen Tausch, Janne Lehtiö§ and Sascha Dietrich§.
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Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
Goroshchuk O, Kolosenko I, Kunold E, Vidarsdottir L, Pirmoradian M, Azimi A, Jafari R*, Palm-Apergi C*. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 35;7 e21741 https://doi.org/10.1096/fj.202100457RR
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses.
Tampere M, Pettke A, Salata C, Wallner O, Koolmeister T, Cazares-Korner A, Visnes T, Hesselman MC, Kunold E, Wiita E, Kalderen C, Lightowler M, Jemth AS, Lehtio J, Rosenquist A, Warpman-Berglund U, Helleday T, Mirazimi A, Jafari R, Puumalainen MR. VIRUSES BASEL 2020 12;12 Viruses https://www.mdpi.com/1999-4915/12/12/1423
In cell CETSA screening identifies known and novel thymidylate synthase inhibitors and slow activation of 5-FU.
Almqvist H*, Axelsson H*, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P. Nature Communications (2016), 7;11040
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The cellular thermal shift assay for evaluating drug target interactions in cells.
Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundbäck T, Nordlund P, Martinez Molina D. Nature protocols (2014) 9;9 2100-22
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Tracking cancer drugs in living cells by thermal profiling of the proteome.
Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G. Science (New York, N.Y.) (2014) 346;6205 1255784
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Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.
Martinez Molina D*, Jafari R*, Ignatushchenko M*, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P. Science (New York, N.Y.) (2013) 341;6141 84-7
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