My research focuses on the development of new NMR methodologies to facilitate drug discovery from assay development to target engagement. Our goal is to bridge the scientific gap between in vitro lead optimization and preclinical studies where many high-affinity compounds fail due to insufficient target engagement in cellular models. Our work spans multiple disciplines, integrating organic chemistry, biochemistry, chemical biology, NMR, and fluorescence.
Antibiotic multidrug resistance is a global challenge that requires a multidisciplinary approach. Among the most concerning factors are metallo-β-lactamase (MBL) enzymes, which are rapidly spreading worldwide. To help combat antibiotic resistance, we are developing new NMR techniques to study MBLs and contribute to this critical field.
Group Members:
Ruisheng Xiong, Assistant Professor
Jonas Ståhle, Senior research engineer
Recruitment of PhD student and postdoctoral fellow ongoing (spring 2025)