Our work is focused on development and evaluation of novel biologicals and combinations thereof, where activation of tumor-specific T cells is key. Our research is also focused on off-target effects related to these therapies, such as interactions with Fc receptors and how this can be studied in humanized model systems. In a human whole blood model we study both adverse events in the form of first-infusion reactions related to interactions with immune cells and cascade systems, as well as recall responses using peptide conjugates incorporating known T cell epitopes and how these responses are modulated by various immune modulating drug candidates.
In addition we have focused our research on tumor localized immunotherapy and specifically studied this in an experimental bladder cancer model. With the aim to locally enhance immune activation in the tumor micro-environment and tumor-draining lymph node while sparing unnecessary systemic activation and thereby avoid induction of auto-immune symptoms.
We have a novel bladder cancer model in which we can study immune-tumor interactions and novel immunotherapies in.
Aikaterini Chourlia, Research assistant and laboratory manager
Aikaterini Nasi, Researcher
Antonino Napoleone, Research assistant
Elinor Larsson, Research assistant
Iliana Kerzeli, PhD student
Ida Olsson, PhD student
Ivan Stepanek, Postdoctor
Martin Lord, Researcher
Mohamed Eltahir (MD), PhD student
Polat Turker, MD and affiliated PhD student
Ulrika Segersten, Affiliated researcher
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.