Key publications

Asp M*, Giacomello S*, Larsson L, Wu C, Fürth D, Qian X, Wärdell E, Custodio J, Reimegård J, Salmén F, Österholm C, Ståhl PL, Sundström E, Åkesson E, Bergmann O, Bienko M, Månsson-Broberg A, Nilsson M, Sylvén C, Lundeberg J. A. Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart. Cell2019 Dec 12;179(7):1647-1660.e19.

Giacomello S, Lundeberg J. Preparation of plant tissue to enable Spatial Transcriptomics profiling using barcoded microarrays. Nature Protocols. 2018 Nov;13(11):2425-2446.

Giacomello S, Salmén F, Terebieniec BK, Vickovic S, Navarro JF, Alexeyenko A, Reimegård J, McKee LS, Mannapperuma C, Bulone V, Ståhl PL, Sundström JF, Street NR, Lundeberg J. Spatially resolved transcriptome profiling in model plant species. Nature Plants. 2017 May 8;3:17061. doi: 10.1038/nplants.2017.61.

Ståhl PL*, Salmén F*, Vickovic S#, Lundmark A#, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J, Frisén J. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science. 2016 Jul 1;353(6294):78-82. doi: 10.1126/science.aaf2403.

Lindholm ME*, Giacomello S*, Werne Solnestam B, Fischer H, Huss M, Kjellqvist S, Sundberg CJ. The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts. PLoS Genetics. 2016 Sep 22;12(9):e1006294.

Nystedt B*, Street NR*, Wetterbom A#, Zuccolo A#, Lin YC#, Scofield DG#, Vezzi F, Delhomme N, Giacomello S, Alexeyenko A, Vicedomini R, Sahlin K, Sherwood E, Elfstrand M, Gramzow L, Holmberg K, Hällman J, Keech O, Klasson L, Koriabine M, Kucukoglu M, Käller M, Luthman J, Lysholm F, Niittylä T, Olson A, Rilakovic N, Ritland C, Rosselló JA, Sena J, Svensson T, Talavera-López C, Theißen G, Tuominen H, Vanneste K, Wu ZQ, Zhang B, Zerbe P, Arvestad L, Bhalerao R, Bohlmann J, Bousquet J, Garcia Gil R, Hvidsten TR, de Jong P, MacKay J, Morgante M, Ritland K, Sundberg B, Thompson SL, Van de Peer Y, Andersson B, Nilsson O, Ingvarsson PK, Lundeberg J, Jansson S. The Norway spruce genome sequence and conifer genome evolution. Nature. 2013 May 30;497(7451):579-84.

Research Interests

Our research group focuses on the fundamental question of how cell localization influences biological processes across different kingdoms and aims to provide clear contributions to the sustainable development goals of the United Nations. Our knowledge is multidisciplinary and unified by the study of spatial gene expression dynamics through the development and application of single-cell and spatial transcriptomics approaches, which are core technologies of our lab.

Current projects on animals

– The plasticity of the mouse heart and brain under microgravity. The final aim is to understand the overall impact of spaceflight at the system level, thus allowing for  improvements in spaceflight conditions for astronauts and to study how extreme stressors affect the human body. The work is conducted in collaboration with NASA (GeneLab).

– The molecular processes of the parasitic worm that causes lymphatic filariasis (also known aselephantiasis), which is considered a neglected tropical disease but affects ~120 million people worldwide. The study is in collaboration with the NIH.

Current projects on plants

– The reproductive molecular dynamics of Norway spruce to promote faster reforestation processes. We are working in collaboration with the Swedish University of Agricultural Sciences (SLU) to understand key differences between the wildtype (25-30 years to reproduction) and the naturally occurring mutant acrocona (3-5 years to reproduction).  

– The plant leaf response to microbial infection. In this project, we are analyzing infection patterns on lab-infected and wild Arabidopsis leaves. The work is performed in collaboration with the Max Planck Institute in Tübingen.

Group members

  • Stefania Giacomello (Group Leader)
  • Aida Verdes (Visiting postdoc – EMBO short-term fellow)
  • Sami Saarenpää (PhD student)
  • Nathan Zivi (co-PhD student)
  • Zaneta Andrusivová (co-PhD student)
  • Hailey Sounart (Research Assistant)
  • Alina Orozco (Research Assistant)


Last updated: 2023-02-17

Content Responsible: David Gotthold(