Fredrik Elinder

Site Director SciLifeLab Linköping, Linköping University

Key publications

Silverå Ejneby M, Wallner B & Elinder F.
2020. Coupling stabilizers open KV1-type potassium channels.
Proc Natl Acad Sci USA 117:27016–27021

Ottosson NE, Silverå Ejneby M, Wu X, Yazdi S, Konradsson P, Lindahl E & Elinder F.
2017. A drug pocket at the lipid bilayer-potassium channel interface.
Sci Adv 3:e1701099

Liin SI, Silverå Ejneby M, Barro-Soria R, Skarsfeldt MA, Larsson JE, Starck Härlin F, Parkkari T, Bentzen BH, Schmitt N, Larsson HP & Elinder F.
2015. Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.
Proc Natl Acad Sci USA 112:5714-5719

Henrion U, Renhorn J, Börjesson SI, Nelson EM, Schwaiger CS, Bjelkmar P, Wallner B, Lindahl E & Elinder F.
2012. Tracking a complete voltage-sensor cycle with metal-ion bridges.
Proc Natl Acad Sci USA 109:8552-8557.

We are interested in the molecular mechanism underlying the opening and closing of voltage-gated ion channels, and how compounds can modify this. We express ion channels in Xenopus oocytes or in human cell lines, and study the voltage-sensing mechanism by measuring ion and gating currents with several electrophysiological methods such as the two-electrode voltage clamp and patch-clamp techniques, bot manual and automatic. Computer simulations are used to understand the molecular effects at the cellular level. We also study how different small-molecule compounds can modify ion channel activity. Specifically we focus on compounds that activate (open) voltage-gated potassium channels. Such compounds can potentially be developed into anti-seizure drugs.

Group members

Johan Brask
Argel Estrada Mondragon
Urban Karlsson
Nina Ottosson
Olle Rönnelid

Last updated: 2023-04-25

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