Virtual Event
May 21, 2026 @ 15:00 – 16:00 CEST
Clinical Genomics Webinar Series
Clinical Genomics Umeå is hosting this webinar as part of the Clinical Genomics Platform webinar series
Redefining Chronic Disease Through Genomics and Multi-Omics: Insights from Dental Caries and Precision Dentistry
| This seminar will present a translational framework integrating clinical cohorts, genomics, and multi-omics to redefine dental caries as a biologically stratified disease. Three prospective studies will be highlighted: a birth cohort (mother–father–child), an adolescent case–referent cohort with 5-year longitudinal follow-up, and an intervention study (n≈500 each). The genomic strategy integrates host and microbial variation to resolve distinct disease pathways. Host stratification based on PRH1, PRH2, and DMBT1–CNV identifies discrete 2- and 3-gene susceptibility profiles that quantitatively predict caries progression. In parallel, genomic variation in surface adhesins and housekeeping genes of Streptococcus mutans reveals high-virulence strains capable of driving disease in genetically non-susceptible individuals, demonstrating independent microbial risk trajectories. Multi-omics analyses, including inflammatory profiling (Olink) and metabolomics of short-chain fatty acids (LC–MS), further define the 3-gene susceptibility profile as a distinct inflammatory caries type. Together, these findings support a shift from descriptive to mechanism-based risk assessment, establishing biologically defined risk groups with predictive value for disease progression. This provides a foundation for precision dentistry through targeted, cost-effective prevention. The seminar will also address key challenges in validating and implementing host–microbe signatures in clinical practice. |
Everyone is welcome so feel free to spread the details with anyone who may be interested. Hope to see you there!
Host: Linda Köhn, Head of Unit, Clinical Genomics Umeå
Invited speaker: Nicklas Strömberg
Department of Odontology, Faculty of Medicine, Umeå University
Google Calendar 
