OligoNova Hub – Oligonucleotide Chemistry

OligoNova Chemistry

Part of the Drug Discovery and Development Platform

OligoNova offers state-of-the-art drug discovery infrastructure and expertise to researchers and supports the translation of fundamental research findings into patient-benefitting therapeutic molecules.

OligoNova Chemistry primarily provides bioinformatic and chemical design, synthesis, purification and analysis of oligonucleotides and their conjugates, but can also provide development of oligonucleotide-based molecular tools for studying processes in living cells

Services

• Organic synthesis of small molecular weight ligands and building blocks
• Bioinformatic selection of sequences of antisense oligonucleotide candidates for their subsequent
  cellular screening
• Iterative design, solid-phase synthesis (SPS) and analysis of oligonucleotide libraries with the aim of
  identification of hit compunds
• SPS and post-synthetic conjugation of oligonucleotides to small molecules, peptides, (bio)polymers,
  and nanoparticles
• Expertise in organic synthesis, medicinal chemistry, drug delivery, design of molecular tools

Applications

• Bioinformatic and chemical design, synthesis, purification and analysis of oligonucleotides and their
  conjugates to setup the molecular basis for development of oligonucleotide therapeutics
• Chemical design, synthesis and characterization of oligonucleotide-based molecular tools for studying
  dynamics of interaction of oligonucleotides with their targets, in vivo biodistribution, and intracellular
  transport

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