Chemical Biology Consortium Sweden

The mission of Chemical Biology Consortium Sweden (CBCS) is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology.  For more information, visit the CBCS external webpage.

CBCS was established in 2010 as a nation-wide infrastructure for chemical biology research consisting of two units, one at Karolinska Intitutet, LCBKI, and the other at Umeå University, LCBU. In 2012 CBCS became an integrated platform at SciLifeLab.

Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 200,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). CBCS coordinates, and makes available, a powerful and integrated platform for the discovery, development and utilization of small-molecules and chemical tools for life-science application. We provides expertise support and experimental resources within assay development, computational chemistry, cheminformatics, chemical library screening and development, medicinal/synthetic chemistry, target identification.

Services

• Access to small-molecule compound libraries and robotic instrumentation
• Expertise in assay development and automation
• High-throughput screening: biochemical target-based, cell-based and phenotypic
• High-throughput imaging technology
• Expertise in screening for antimicrobial compounds and plant-based screens
• Hit identification and optimization
• Computational chemistry and modelling
• Medicinal chemistry expertise
• Chemical proteomics & target identification of small molecule ligands
• Mechanism of Action studies
• The Drug Repurposing set from SPECS is now available through Compound Center

For more Information on our available services, visit our website.

Applications

CBCS works according to a collaborative research model based on mutual commitment from our group and the involved Investigator.

For more substantial projects, a formal process initiated by an application is implemented to ensure that resources are prioritized based on transparent criteria, such as scientific excellence, novelty, technical feasibility and relevance. Our Project Review Committee (PRC) consists of CBCS-independent experts in the chemical biology research field, also including industry representation.

Upcoming dates for Project Review Committee (PRC) meeting and the proposal submission deadline are published on our website www.cbcs.se