[The Svedberg seminar] – Metabolic Regulation of Longevity from Organelle to Organism
September 24, 2025 @ 15:15 – 16:15 CEST
Meng Wang
PhD, Senior Group Leader
Janelia Research Campus, US
Bio
Dr. Meng Wang is currently a Senior Group Leader at HHMI Janelia Research Campus. She received a B.S. degree from Peking University, China in 2001 and a Ph.D. degree from University of Rochester in 2005. After being a postdoctoral follow at Harvard Medical School, Dr. Wang joined the faculty of Baylor College of Medicine in 2010. Before moving to Janelia in 2022, she was an HHMI Investigator, a Professor and the Robert C. Fyfe Endowed Chair on Aging at Baylor College of Medicine (BCM), as well as a co-director of the BCM Genetics and Genomics Graduate Program. Dr. Wang’s research focuses on metabolic signals in regulating lifespan and healthspan, through harnessing the power of genomic screening, multi-omic profiling, chemical engineering and optical biophysics. Her group uncovered that lysosomes act as a central hub for integrating metabolism and signal transduction to modulate cellular homeostasis and organismal fitness, and demonstrated a novel mode of signaling communication between bacteria and mitochondria in regulating host’s lipid metabolism and longevity. Technological developments in Dr. Wang’s laboratory have provided brand new ways to visualize and track metabolic molecules as a function of time and space in living cells and organisms. She is the recipient of NIH Director’s Pioneer Award, Peter O’Donnell Award, HHMI Faculty Scholar Award, ASCB Gibco Emerging Leader Prize, ASCB Early Career Life Scientist Award, and Glenn Award for Research in Biological Mechanisms of Aging. She is an elected fellow of the American Association for the Advancement of Science and the American Society for Cell Biology.
Metabolic Regulation of Longevity from Organelle to Organism
Dr. Wang’s research aims to decode the chemical language that governs cellular homeostasis and organismal healthspan. A central question in biology is how cells maintain homeostasis while adapting to continuous internal and external fluctuations. Metabolic activity, a cornerstone of cellular homeostasis, generates metabolites that are essential for cellular functions and highly conserved across species. Her lab has discovered that these metabolites can act as communication cues operating across multiple spatial scales, from organelles to whole organisms, through specific signaling mechanisms. This metabolic perspective links cellular dynamics with organismal physiology, offering novel strategies to promote healthy aging and longevity. In parallel with these mechanistic studies, her group has contributed to the development and application of cutting-edge imaging platforms that enable the study of metabolism in both space and time. These technological advances have revealed previously unknown spatial heterogeneity in metabolic organization and allowed high-resolution tracking of metabolic changes during aging
Host: Yunjian Xu yunjian.xu@mcb.uu.se, UU
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