[The Svedberg seminar] – Super-resolution imaging of chromatin in health and disease
February 16, 2026 @ 14:00 – 15:00 CET
Melike Lakadamyali
Professor
University of Pennsylvania, USA
Bio
Dr. Lakadamyali obtained her BS in Physics in 2001 from the University of Texas, Austin and her PhD in Physics in 2006 from Harvard University. Dr. Lakadamyali started her independent group at ICFO-Institute of Photonic Sciences in Barcelona in 2010 and was awarded tenure in 2015. In 2017 she moved to the University of Pennsylvania´s Department of Physiology at the Perelman School of Medicine as an Assistant Professor, was promoted to Associate Professor in 2020 and Full Professor in 2024.
Super-resolution imaging of chromatin in health and disease
Super-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization, while also identifying the specific chromatin features that drive classification, thus offering mechanistic insight into cell-state regulation.
Host: Sebastian Deindl sebastian.deindl@icm.uu.se, UU
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