Postdoctoral Researcher in single-cell genomics
Do you want to contribute to top quality medical research?
Are you interested in non-genetic cellular heterogeneity and their role in disease? Would you like to contribute to the development of cutting-edge genome-wide technologies? Come and join us at SciLifeLab!
The Department of Microbiology, Tumor and Cell Biology conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Our laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core units, and is home to one of the largest sequencing cluster in Europe. SciLifeLab Stockholm is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH) and Stockholm University, and hosts research groups with diverse backgrounds and expertise, including basic biology, drug discovery, genomics, bioengineering, and translational medicine.
The research group
Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.
Your mission
The available postdoctoral position concerns developing and applying novel approaches to study the crosstalk between gene expression and metabolism at single cell level. The candidate will use those technologies to investigate singe-cell heterogeneity in cancer cell lines and investigate how altered metabolic states shape gene expression. The candidate is expected to contribute his/her own ideas to the common goal of understanding how altered cellular metabolism contributes to the appearance of divergent cellular phenotypes. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate will be responsible for integrating different kinds of biological information to answer relevant questions. The successful candidate will take a strong lead in the experimental design, and collaborate with other team members. The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.
The candidate will work in a project in collaboration with our colleagues at MDC-BIMSB (Piazza lab: https://www.mdc-berlin.de/piazza ; https://thewittysquare.eu ; https://www.mdc-berlin.de/bimsb). Applicants interested in starting a postdoctoral project at Karolinska Institute for one year and continue his/her training in Berlin are specially encouraged to apply.
Your profile
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.
Applicants to this position should have a PhD in Molecular Biology, Genetics, or related fields. The successful applicant should also have experience interpreting biological data and experimentally testing their hypothesis. Previous experience in Eukaryotic transcriptional regulation and metabolism will be highly considered. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential. Preferred experience also includes familiarity with epigenetics, single-cell technologies, tissue culture, immunohistochemistry, bioinformatics, NGS data analysis and molecular biology techniques. Good interpersonal skills and ability to work in teams is essential. Previous experience in proteomics and biochemistry will be meriting. Applicants wishing to integrate experimental and computational biology approaches are also encouraged to apply.
What do we offer?
Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.
Location: Solna
| Type of employment | Temporary position longer than 6 months |
|---|---|
| Contract type | Full time |
| First day of employment | According to agreement |
| Salary | Monthly salary |
| Number of positions | 1 |
| Working hours | 100 % |
| City | Solna |
| County | Stockholms län |
| Country | Sweden |
| Reference number | STÖD 2-674/2021 |
| Contact | Vicente Pelechano Garcia, vicente.pelechano.garcia@ki.se |
| Union representative | Taher Darreh-Shori, SACO, taher.darreh-shori@ki.se Carina Eklund, OFR, carina.eklund@ki.se Henry Wölling, SEKO, henry.wolling@ki.se |
| Published | 08.Feb.2021 |
| Last application date | 07.Mar.2021 11:59 PM CET |