Advancing Network Biology: The launch of FunCoup 6
January 27, 2025 @ 15:00 – 17:00 CET
Network biology is a new paradigm to understand the complex interactions of the molecules in an organism using an integrative and systems approach. By applying network analysis in their research, scientists can e.g. generate new hypotheses of molecular mechanisms, perform functional annotation of network modules, or predict new drug targets.
The comprehensive network database FunCoup (https://FunCoup.org/) is a resource that can be used to answer various research questions at the systems biology level. The new release 6 (http://www.ncbi.nlm.nih.gov/pubmed/39530220/) is a major update to the FunCoup networks and website, which provides researchers with significantly improved capabilities for exploring the functional coupling interactome. The key innovations include:
- Increased regulatory coverage: FunCoup 6 now includes over half a million directed gene regulatory links in the human network alone, offering expanded insights into transcriptional regulation.
- Increased coverage to 640 species in total.
- New, redesigned website with enhanced API functionalities.
- Advanced integrated tools for network analysis: TOPAS for disease module identification, ANUBIX for pathway enrichment analysis, and Maxlink for disease gene prioritization.
- New comparative interactomics search mode that queries each species network independently.
FunCoup is also available as a Cytoscape app, and was shown to exhibit superior performance compared to other functional association networks. At this event, the new FunCoup website and its unique capabilities for network exploration and analysis will be demonstrated.
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