Clinical Talks: Blood-based methods for predicting the day of labor
October 29 @ 09:00 – 09:30 CEST
On October 29, we will host a dual presentation with Dr. Ina Stelzer and Associate Professor Brice Gaudillière. At the Stanford School of Medicine Clinical Gaudillière laboratory, Ina and Brice have developed a groundbreaking multi-omics approach to track the maternal metabolome, proteome and immunome to predict exact labor onset. Estimating the time of delivery is of high clinical importance to minimize pre- and post-term deviations causing complications and suffering with ultimately more streamlined use of medical resources for a sustainable future.
Ina is a molecular biologist and immunologist with an extensive background in pregnancy immunology. She obtained her PhD in Immunology 2017 from the University Medical Center Hamburg-Eppendorf (part of the University of Hamburg). Her work then focused on the immunology of pregnancy and feto-maternal immune crosstalk with a focus on fetal origin of disease development later in life. Ina is currently pursuing her postdoctoral research at Stanford University in the Gaudillière laboratory. Building on her expertise in preclinical (mouse) models of pregnancy and translational systems immunology, her research leverages state-of-the-art single cell proteomic techniques (suspension and imaging mass cytometry) to study feto-maternal immune adaptations in healthy and pathological pregnancies with the goal to improving the health of mothers and their children. Her current K99/R00-funded work investigates the neuro-immune axis in normal pregnancy and the pathogenesis of pregnancy complications. While at Stanford during 2021, Ina also recently completed the prestigious Stanford University Graduate School of Business organized Stanford Ignite certificate program.
Associate Professor Brice Gaudillière initially studied Engineering at Ecole Polytechnique in Paris before completing an MD-PhD degree from the Harvard-MIT Health Sciences and Technology program in 2009. During his postdoctoral fellowship at Stanford University in Dr. Garry Nolan’s laboratory, he developed and standardized a pipeline to implement CyTOF in clinical studies. Brice is also a Board Certified Anesthesiologist and works clinically in the operating room 25% of his time.
Gaudilliere’s research group combines high parameter mass cytometry (suspension and imaging mass cytometry) with other proteomics approaches to study how the human immune system responds and adapts to physiological or pathological stressors. Ongoing studies in the Gaudilliere lab focus on several clinical scenarios including, 1) surgical recovery and traumatic injury (NIGMS R35, Stanford ITI, Anesthesia department FIDL, 2) pregnancy and preterm birth (Doris Duke Foundation, Stanford Prematurity Center grants from the Bill and Melinda Gates and the March of Dimes Foundation, 3) Host immune response to COVID-19 infection (FAST grant), 4) neurocognitive recovery after stroke (PHIND grant).
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