Regulation of protein disaggregation in primates
March 28, 2023 @ 13:00 – 14:00 CEST
Cells have evolved multitiered protein quality control systems to help maintain protein homeostasis, but under acute or chronic proteotoxic stresses, these systems overload and result in accumulation of toxic protein aggregates. Decreased cellular capacity in aggregate clearance could trigger cell dysfunction and death leading to disease and ageing. Human cells possess an Hsp70-based disaggregase system to resolve a wide range of protein aggregates. It is not clear how these disaggregases are assembled and regulated in mammals. We report the identification of a dedicated pathway for rapidly assembling protein disaggregases during stress recovery after protein damage and outlines how aggregate clearance is orchestrated in primate cells.