Single-cell and spatial atlases of the adult and developing human brain
September 7 @ 14:00 – 15:00 CEST
Recently, we have generated single-cell atlases of the adult and developing human brain using a combination of single-cell RNA sequencing and spatial transcriptomics. In the adult, we found an unexpectedly high diversity of neuronal types especially in the midbrain and hindbrain, with conservatively more than 3000 distinct types. In the developing human brain, we revealed highly refined trajectories of differentiation of cortical neurons. We further found that astrocytes and oligodendrocytes were regionally patterned, and that these region-specific types persisted in the adult. These findings may provide a basis for the brain region-specific occurrence of pediatric brain tumors.
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Speaker
Sten Linnarsson
Research Division of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden
Human Developmental Dell Atlas (HDCA) is the Swedish effort within the human cell atlas (HCA), one of the largest international scientific projects. The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq, Spatial Transcriptomics, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease.
The HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. Seminars will be held at SciLifeLab Gamma building on Wednesdays at 14:00 or 15:00 and also via Zoom. After each seminar, we will have up to 30 min round up discussions with the speaker on how you can contribute to the atlas!
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