As Head of the CRISPR Functional Genomics Unit and Co-Director and Coordinator of the SciLifeLab platform for Chemical Biology and Genome Engineering, I am dedicated to providing researchers with access to state-of-the-art technologies that harness the full potential of CRISPR/Cas systems. This includes enabling applications across a wide spectrum, from fundamental biology to translational approaches.

My group’s own research focuses on the development and implementation of next-generation CRISPR/Cas technologies in basic research. Current projects span from defining the genetic factors that influence CRISPR/Cas delivery into cells, to applying base editing for scanning mutagenesis screens, and refining methodologies for pooled genetic screening using diverse CRISPR/Cas modalities. In addition, we are developing strategies for high-content profiling screens that integrate pooled genetic perturbations with rich phenotypic readouts, such as single cell transcriptomics, microscopic phenotyping, or spatial transcriptomics.

Our work is supported by SciLifeLab, the Infrastructure Council at Karolinska Institutet, and the Swedish Research Council (Vetenskapsrådet).

Group Members

Soniya Dhanjal
Olga Khorosjutina
Anneke Navis
Hirofumi Noguchi
Miriam Selle