A recent paper in Science Signaling highlights a family of receptors known as Frizzleds as potential drug targets in treatment of cancer, fibrosis and cardiovascular diseases. The study is led by Gunnar Schulte (Karolinska Institutet) and researchers from Germany, and conducted in collaboration with SciLifeLab Fellow Jens Carlsson (Uppsala University/SciLifeLab).

The team identifies how these Frizzleds receptors are activated in the cell membrane and the processes that are then triggered within the cell. More specifically, they show that one of the receptors in the family, Frizzled 5, could be targeted by drugs in the same way as histamine, adrenaline or dopamine receptors.

Read the full paper in Science Signaling

Read a news article by Karolinska Institutet

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Ok!Read More
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled

Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

Non-necessary

Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.