A recent paper in Science Signaling highlights a family of receptors known as Frizzleds as potential drug targets in treatment of cancer, fibrosis and cardiovascular diseases. The study is led by Gunnar Schulte (Karolinska Institutet) and researchers from Germany, and conducted in collaboration with SciLifeLab Fellow Jens Carlsson (Uppsala University/SciLifeLab).
The team identifies how these Frizzleds receptors are activated in the cell membrane and the processes that are then triggered within the cell. More specifically, they show that one of the receptors in the family, Frizzled 5, could be targeted by drugs in the same way as histamine, adrenaline or dopamine receptors.
Read the full paper in Science Signaling