Head of Unit: CRISPR Functional Genomics
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E.
Rapid genome editing by CRISPR-Cas9-POLD3 fusion.
Elife. 2021 Dec 13;10:e75415. doi: 10.7554/eLife.75415. PMID: 34898428.
Iyer VS, Jiang L, Shen Y, Boddul SV, Panda SK, Kasza Z, Schmierer B, Wermeling F.
Designing custom CRISPR libraries for hypothesis-driven drug target discovery.
Comput Struct Biotechnol J. 2020 Aug 18;18:2237-2246. doi: 10.1016/j.csbj.2020.08.009. PMID: 32952937.
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J.
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.
Nat Med. 2018 Jul;24(7):927-930. doi: 10.1038/s41591-018-0049-z. Epub 2018 Jun 11. PMID: 29892067.
Schmierer B, Botla SK, Zhang J, Turunen M, Kivioja T, Taipale J.
CRISPR/Cas9 screening using unique molecular identifiers.
Mol Syst Biol. 2017 Oct 9;13(10):945. doi: 10.15252/msb.20177834. PMID: 28993443.
Persson J, Schmierer B.
Sequence Diversification Screens with CRISPR-Cas9-Guided Base Editors.
In: Maresca M, Deswal S, editors. Genome Editing in Drug Discovery. John Wiley & Sons; 2022 Mar 17. https://doi.org/10.1002/9781119671404.ch11
My research is focused on development and implementation of novel applications of CRISPR systems in basic research. Examples include defining genetic factors affecting the delivery of CRISPR/Cas into cells, applying base-editing for scanning mutagenesis screens, and refining methods for pooled genetic screening with different CRISPR/Cas modalities.
Group Members
Soniya Dhanjal
Olga Khorosjutina
Anneke Navis
Miriam Selle
Last updated: 2025-01-15
Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)