Jochen Schwenk

Platform Scientific Director – Clinical Proteomics and Immunology, KTH

Keywords
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Key publications

Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections.
Fredolini C, Dodig-Crnković T, Bendes A, Dahl L, Dale M, Albrecht V, Mattsson C, Thomas CE, Torinsson Naluai Å, Gisslen M, Beck O, Roxhed N, and Schwenk JM
CommsMed. 2024. doi: 10.1038/s43856-024-00480-4

Multiplexed selectivity screening of anti-GPCR antibodies.
Dahl L, Kotliar IB, Bendes A, Dodig-Crnković T, Fromm S, Elofsson A, Uhlén M, Sakmar TP, Schwenk JM.
Sci Adv. 2023 May 3;9(18):eadf9297. doi: 10.1126/sciadv.adf9297.

Genetics meets proteomics: perspectives for large population-based studies.
Suhre K, McCarthy MI, Schwenk JM.
Nat Rev Genet. 2021 Jan;22(1):19-37. doi: 10.1038/s41576-020-0268-2.

Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
Roxhed N, Bendes A, Dale M, Mattsson C, Hanke L, Dodig-Crnković T, Christian M, Meineke B, Elsässer S, Andréll J, Havervall S, Thålin C, Eklund C, Dillner J, Beck O, Thomas CE, McInerney G, Hong MG, Murrell B, Fredolini C, Schwenk JM.
Nat Commun. 2021 Jun 17;12(1):3695. doi: 10.1038/s41467-021-23893-4.

Advances and Utility of the Human Plasma Proteome.
Deutsch EW, Omenn GS, Sun Z, Maes M, Pernemalm M, Palaniappan KK, Letunica N, Vandenbrouck Y, Brun V, Tao SC, Yu X, Geyer PE, Ignjatovic V, Moritz RL, Schwenk JM. J
Proteome Res. 2021 Dec 3;20(12):5241-5263. doi: 10.1021/acs.jproteome.1c00657.

Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling.
Dodig-Crnković T, Hong MG, Thomas CE, Häussler RS, Bendes A, Dale M, Edfors F, Forsström B, Magnusson PKE, Schuppe-Koistinen I, Odeberg J, Fagerberg L, Gummesson A, Bergström G, Uhlén M, Schwenk JM.
EBioMedicine. 2020 Jul;57:102854. doi: 10.1016/j.ebiom.2020.102854.

SciLifeLab / Contact / Jochen Schwenk

Jochen Schwenk

Research Interests

Blood offers comprehensive insights into our health and disease physiology. We develop and employ advanced proteomics techniques to investigate the proteins circulating in the blood to enhance our understanding of human health and disease conditions. These efforts are supported by the resources and knowledge provided by the Human Protein Atlas and advanced affinity proteomics technologies. 

In our research projects, we primarily study metabolic, cardiovascular, respiratory, and inflammatory diseases, breast cancer, and overall wellness. Recognizing the challenges in studying circulating biomarkers, we carefully design our studies and account for different pre-analytical biases. In addition to large-scale analysis, we create assays tailored to specific targets and explore different samples, including dried blood spots and those obtained from microsampling techniques. We utilize various approaches, including classical, multivariate, and data-driven analysis, to unravel the biological significance of numerous proteins. Our goal is to delineate the molecular architecture of the circulating proteome across individuals, various health, treatment effects and disease states. This aims to establish clinically relevant analyses of the circulating proteome that can contribute to an improved understanding of human biology.

Publication List

https://scholar.google.se/citations?user=gL3i6scAAAAJ

Group members

Current

  • Prof Jochen M Schwenk (Group leader)
  • Annika Bendes (PhD Student), 
  • Leo Dahl (PhD student),
  • William Stauch (PhD student) 
  • Anna Gardell (Master student)
  • Hampus Hagelin (Master student)

Co-supervisor to

  • Thanadol Sutantiwanichkul (PhD student)
  • Szabolcs Simon-Guth (PhD student)

Associated Infrastructure Unit

  • Dr. Claudia Fredolini (PhD, Head of Affinity Proteomics Stockholm)
  • Matilda Dahle (Research engineer)
  • Maryam Sahi (Research engineer)
  • Sarah Andersson (Research engineer)

Alumni

  • Dr. Tea Dodig-Crnkovic (PhD student)
  • Dr. Ulrika Qundos (PhD student), 
  • Dr. Sanna Byström (PhD student), 
  • Lic Kimi Drobin (Licentiate student), 
  • Dr. Cecilia Engel Thomas (Postdoc), 
  • Dr. Mun-Gwan Hong (Resercher), 
  • Dr. Philippa Pettingill (Researcher), 
  • Dr. Ragna Häussler (Postdoc), 
  • Dr. Claudia Fredolini (Postdoc),
  • Dr. Spyros Darmanis (Postdoc), 
  • Dr. Björn Winckler (Postdoc), 
  • Dr. Ilana Kotliar (visiting PhD student, Rockefeller University), 
  • Dr. Emily Lorenzen (visiting PhD student, Rockefeller University), 
  • Cecilia Mattsson (Research engineer), 
  • Elin Birgersson (Research Engineer), 
  • Dr. Arash Zandian (PhD student)*, 
  • Dr. Anna Häggmark-Månberg (PhD student)*, 
  • Dr. Burcu Ayoglu (PhD student)*, 
  • Dr. David Just (PhD student)*, 
  • Dr. Maja Neiman (PhD student)*, 
  • Dr. Mahya Dezfouli (PhD student)*, 
  • Dr. Maria Mikus (PhD student)*, 
  • Dr. Elisa Pin (Postdoctoral)*,
  • Dr. Frauke Henjes (Postdoc)*, 
  • Dr. Julie Bachmann (Postdoc)*, 
  • Amelie Vogt (Erasmus student)
  • Vincent Albrecht (Erasmus student)
  • Paul Boulouednine (Erasmus student),
  • Svenja Wingerter (Erasmus student), 
  • Kristin Stirm (Erasmus student).

* Co-supervisor

Contact

jochen.schwenk@scilifelab.se

Last updated: 2024-04-23

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