Mathias Uhlén
Mathias Uhlén
KTH Royal Institute of Technology
Research interests
The research of Professor Uhlen is focused on protein science, antibody engineering and precision medicine and range from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology. The research has resulted in more than 550 publications with a current h-index of 97 (Google Scholar). His group was the first to describe a number of innovations in science including:
- engineered protein A and protein G for purification of antibodies
- the concept of affinity tags for purification of recombinant fusion proteins
- solid phase methods for DNA handling using the biotin-streptavidin system
- Pyrosequencing leading to the first next generation sequencing instrument (454)
- Affibodies – protein binders now used in various therapeutic applications
Since 2003, he has led an international effort to systematically map the human proteome with antibodies and to create an open source knowledge-based resource called the Human Protein Atlas7,8,9 (www.proteinatlas.org). From 2010-2015, he was the founding Director of the Science for Life Laboratory (www.scilifelab.se).
Group members
Fredrik Edfors, graduate student
Evelina Sjöstedt, graduate student
Linn Fagerberg, scientistBjörn Forsström, scientist
Tova Alm, scientist
Åsa Sievertzon, scientist
Gianluca Maddalo, scientist
Kalle von Felitzen, bioinformatics
Per Oksvold, bioinformatics
Mattias Forsberg, bioinformatics
Martin Zwahlen, bioinformatics
Key publications
- Uhlen et al (1984) J Biol Chem 259: 1695-702
- Uhlen (1989) Nature 340: 733-4
- Ronaghi, Uhlen and Nyren (1998) Science 281: 363-5
- Nord et al (1997) Nature Biotechnology 15: 772-7
- Uhlen et al (2010) Nature Biotechnology 28: 1248-50
- Uhlen et al (2015) Science 347: 1260419
- Uhlen et al (2016) Mol Systems Biol., 4;12:862
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