Key publications

Uhlen et al (2015) Science 347: 1260419

Uhlen et al (2016) Mol Systems Biol., 4;12:862

Uhlen et al (2017) Science 357: 6352

Uhlen et al (2019) Science Signaling 12: 609  

Uhlen et al (2019) Science 366: 6472

Sjöstedt et al (2020) Science 367: 6482

Mathias Uhlén

Research interests

The research of Professor Uhlen is focused on data-drive life science, including systems biology and precision medicine ranging from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology. The research has resulted in more than 650 publications with a current h-index of 122 (Google Scholar). His group was the first to describe a number of innovations in science including:

  • Engineered protein A and protein G for purification of antibodies
  • The concept of affinity tags for purification of recombinant fusion proteins
  • Solid phase methods for DNA handling using the biotin-streptavidin system
  • Pyrosequencing leading to the first next generation sequencing instrument (454)
  • Affibodies – protein binders now used in various therapeutic applications

Since 2003, he has led an international effort to systematically map the human proteome with antibodies and to create an open source knowledge-based resource called the Human Protein Atlas. From 2010-2015, he was the Founding Director of the Science for Life Laboratory, SciLifeLab.

Group members

Fredrik Edfors, scientist
Linn Fagerberg, scientist
Åsa Sievertzon, scientist
Cristina Al-Khalili, scientist
Wen Zhong, post-doc
Andreas Hober, graduate student
David Kotol, graduate student
Max Karlsson, graduate student
Kalle von Felitzen, bioinformatics
Per Oksvold, bioinformatics
Mattias Forsberg, bioinformatics
Martin Zwahlen, bioinformatics
Fredric Johansson, bioinfomatics


Last updated: 2022-11-30

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