My research is centered on the development of new computational and experimental methods to simulate, quantitate and visualize drug distribution at the tissue, cellular and subcellular scales, and on applying these methods to understand how the chemical features of drug molecules determine their cellular transport, subcellular distribution and target engagement. My research interests also include how ligands outside the traditional small-molecule chemical space—oligonucleotides, PROTACs, macrocycles and other classes of large bioactive molecules—can be successfully developed into drugs.
Group members
Emma Inganäs-Söderlund
MyLan Eklund
Antonio Carlesso
Ruwei Yao
Abhimanyu Thakur
Zdenek Vavrina (external)
Merran Bryford (external)
Parisa Rabieifar (external)