Pär Matsson

Platform Scientific Director – Drug Discovery and Development, University of Gothenburg

Key publications

Over B & Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD 4th, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, Kihlberg J.
Structural and conformational determinants of macrocycle cell permeability.
Nature Chem. Biol., 2016 (12)12:1065-1074.

Rossi Sebastiano M, Doak BC, Backlund M, Caron G, Ermondi G, Over B, Poongavanam V, Matsson P & Kihlberg J.
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5. J.
Med. Chem. 2018 (61)9:4189-4202

Mateus A, Treyer A, Wegler C, Karlgren M, Matsson P, Artursson P.
Intracellular drug bioavailability: a new predictor of system dependent drug disposition.
Sci. Rep. 2017 (7)43047, doi: 10.1038/srep43047.

Matsson P, Fenu LA, Lundquist P, Wisniewski J, Kansy M, Artursson P.
Quantifying the impact of transporters on cellular drug permeability. Trends Pharmacological Sciences.
Published online 2015, doi: 10.1016/j.tips.2015.02.009.

Matsson P, Pedersen JM, Norinder U, Bergström CA, Artursson P.
Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.
Pharm. Res., 2009(26)8:1816-1831.

My research is centered on the development of new computational and experimental methods to simulate, quantitate and visualize drug distribution at the tissue, cellular and subcellular scales, and on applying these methods to understand how the chemical features of drug molecules determine their cellular transport, subcellular distribution and target engagement. My research interests also include how ligands outside the traditional small-molecule chemical space—oligonucleotides, PROTACs, macrocycles and other classes of large bioactive molecules—can be successfully developed into drugs.

Group members

Emma Inganäs-Söderlund
MyLan Eklund
Antonio Carlesso
Ruwei Yao
Abhimanyu Thakur
Zdenek Vavrina (external)
Merran Bryford (external)
Parisa Rabieifar (external)

Last updated: 2024-01-26

Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)