My research focuses on cardiovascular disease, the leading cause of death worldwide. Specifically, how blood flow forces, sensed by endothelial cells, shape cardiovascular development and function. Using zebrafish as a model organism, my work integrates genetic tools, high-resolution live imaging, single-cell omics, and technology optimization. Overall, I aim to unravel key processes essential for cardiovascular function and develop tools with broad research and therapeutic applications.
Thomas Juan
Uppsala University
Key Publications
Induction of a transcriptional adaptation response by RNA destabilization events
EMBO Reports, 2025
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Nature, 2025
A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish
PLOS Genetics, 2025
flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
Development, 2024
egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis
Science Advances, 2024