My research focuses on cardiovascular disease, the leading cause of death worldwide. Specifically, how blood flow forces, sensed by endothelial cells, shape cardiovascular development and function. Using zebrafish as a model organism, my work integrates genetic tools, high-resolution live imaging, single-cell omics, and technology optimization. Overall, I aim to unravel key processes essential for cardiovascular function and develop tools with broad research and therapeutic applications.
Thomas Juan
Uppsala University
Key Publications
Mustn1b is required for cardiomyocyte dedifferentiation and heart regeneration in zebrafish
Developmental Biology, 2026
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Science Advances, 2026
Time-resolved single-cell transcriptomics maps zebrafish heart development
Cell Reports, 2026
Induction of a transcriptional adaptation response by RNA destabilization events
EMBO Reports, 2025
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Nature, 2025