My research focuses on cardiovascular disease, the leading cause of death worldwide. Specifically, how blood flow forces, sensed by endothelial cells, shape cardiovascular development and function. Using zebrafish as a model organism, my work integrates genetic tools, high-resolution live imaging, single-cell omics, and technology optimization. Overall, I aim to unravel key processes essential for cardiovascular function and develop tools with broad research and therapeutic applications.
Thomas Juan
Uppsala University
Key Publications
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Science Advances, 2026
Time-resolved single-cell transcriptomics maps zebrafish heart development
Cell Reports, 2026
Induction of a transcriptional adaptation response by RNA destabilization events
EMBO Reports, 2025
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Nature, 2025
A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish
PLOS Genetics, 2025