Vasili Hauryliuk

Key publications

Mets T, Kurata T, Ernits K, Johansson JOJ, Craig SZ, Evora GM, Buttress JA, Odai R, Coppieters’t Wallant K, Nakamoto JA, Shyrokova L, Egorov AA, Doering CR, Brodiazhenko T, Laub MT, Tenson T, Strahl H, Martens C, Harms A, Garcia-Pino A, Atkinson GC, Hauryliuk V (2024) Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems. Cell Host & Microbe, 32(7):1059-1073.e8.

Zhang T, Tamman H, Wallant KC, Kurata T, LeRoux M, Srikant S, Brodiazhenko T, Cepauskas A, Talavera A, Marteens C, Atkinson GC, Hauryliuk V, Garcia-Pino A, Laub MT (2022) Direct activation of an innate immune system in bacteria by a viral capsid protein. Nature, 612(7938):132-140

Crowe-McAuliffe C, Murina V, Kasari M, Takada H, Turnbull KJ, Polikanov YS, Sundsfjord A, Hegstad K, Atkinson GC, Wilson DN, Hauryliuk V (2022) Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics. Nature Communications, 13(1):1860

Roghanian M, Van Nerom K, Takada H, Caballero-Montes J, Tamman H, Dzhygyr I, Talavera A, Kudrin P, Atkinson GC, Ekström S, Garcia-Pino A, Hauryliuk V (2021) (p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains. Molecular Cell, 81(16), 3310-3322.e6

Kurata T, Brodiazhenko T, Oliveira SRO, Roghanian M, Turnbull KJ, Ondřej Bulvas, Takada H, Pohl R, Garcia-Pino A, Rejman D, Tenson T, Atkinson GC, Hauryliuk V (2021) RelA-SpoT Homologue toxins modify the CCA end of tRNA to inhibit protein synthesis. Molecular Cell, 81(15): 3160-3170.e9

Crowe-McAuliffe C, Takada H, Murina V, Polte C, Kasvandik S, Tenson T, Ignatova Z, Atkinson GC, Wilson DN, Hauryliuk V (2021) Structural basis for bacterial ribosome-associated quality control by RqcH and RqcP. Molecular Cell, 81(1):115-126.e7

My research interests are molecular mechanisms and evolution of ribosomal protein synthesis and its regulation. The lab is using a combination of biochemical, microbiological, next-generation sequencing (ribosome profiling and 5PSeq) and structural (cryo-EM) approaches to tackle two complementary research directions:

  1. Phage-bacteria interactions: antiphage defence mechanisms, toxin-antitoxin systems
  2. Protein synthesis on the ribosome: antibiotics, antibiotic resistance, stress sensing and signalling, protein quality control

Last updated: 2024-10-02

Content Responsible: Hampus Persson(hampus.persson@scilifelab.uu.se)