Medicinal Chemistry Hit2Lead is a unit belonging to the Drug Discovery and Development platform (DDD) at SciLifeLab (Science for Life Laboratory). We design and synthesize new compounds to accelerate academic drug discovery projects with the aim to identify a compound with a promising profile for proof-of-concept animal studies. Drug discovery is a complex area and to be successful we need to understand the underlying cause of the disease and evaluate the potential and limitations with the different compounds we prepare. We do this in collaboration with the other units at SciLifeLab DDD. We work closely together with our chemistry colleagues in Uppsala.
“We can analyze and evaluate compounds.* We can design and prepare new compounds. We have experience of drug discovery compounds. We are medicinal/computational/organic chemists and are here to catalyze you research in drug discovery.”
*Or “molecules”, “drugs”, “active substances”, “chemicals”, “screening hits” etc. It does not matter. We work with them all.
As part of a new modality initiative within DDD a PROTAC technology platform has been initiated at the Hit2Lead unit. Modulating diseases by small molecules has historically been limited to either inhibition or activation of biological targets. With the new PROTAC technology it is possible to degrade a target (stop its activity completely) by hijacking the endogenous ubiquitination pathway.
A toolbox with different E3-ligase and linkers will be finished during 2020 that will enable fast evaluation if a PROTAC approach is applicable to modulate the target of interest.
We want to collaborate with you. The initial hit compound showing activity at your target can be obtained through e.g. fragment-based drug discovery (FBDD) technologies, rational drug design, or from high-throughput screening (HTS) capabilities available at SciLifeLab via CBCS etc. Please contact us for a discussion around your ongoing research.
Mailing Address
SciLifeLab
Medicinal Chemistry – Hit2Lead
Box 1031
171 21 Solna
Sweden
Visiting Address/Deliveries
SciLifeLab
Medicinal Chemistry – Hit2Lead
Tomtebodav 23A
171 65 Solna
Sweden