Medicinal Chemistry – Lead Identification

The Medicinal Chemistry – Lead Identification unit will take on, explore, and optimize molecules in drug discovery projects. Synthetic and computational chemistry will be at the core of the so-called Design-Make-Test-Analyze cycle that characterizes a small molecule drug discovery program. The mission is to deliver small drug-like molecules with potency, selectivity, physicochemical and ADMET properties of sufficient quality to allow proof-of-concept animal studies. We work in close collaboration with our colleges in the hit-to lead unit.

A technology development program on DNA-encoded libraries was initiated in 2018. A dedicated instrument park with a LC-MS for analysis of DNA-conjugated molecules as well as a preparatory LC and a gel electrophoresis system is available. The first SciLifeLab DNA-encoded library containing one million compounds is available for smailto:johan.wannberg@scilifelab.uu.seelections. To learn more about the project, contact Johan Wannberg.

Services

• Organic synthesis of bioactive compounds (small molecules and peptides).
• Medicinal chemistry expertize.
• Iterative design, synthesis and analysis of assay data to improve compound properties.
• Compound characterization, structure determination and purity analysis.
• Quantitative structure based activity relationships.
• Scale-up synthesis of bioactive compounds.
• Selection and purchase of commercial compounds.
• Synthesis of reference compounds.
• Competitive Intelligence
• In collaboration with Medicinal chemistry Hit2Lead: Computer-based drug design

Equipment

• Analytical UHPLC-MS.
• Automated flash chromatography systems.
• GCMS instruments.
• Hardware and software for Computer-Aided Drug Design.
• Microwave batch reactors.
• Microwave continuous flow reactors.
• NMR spectrometers.
• Peptide synthesizer.
• Preparative HPLC instruments.

Using the unit

Please contact the Head of Unit, Ulrika Yngve.