Medicinal Chemistry – Lead Identification

Infrastructure Unit

Recent user publications

The publications in this database are the result of research conducted at the units of SciLifeLab – both in user projects and technology development.


Anders Karlén, Platform Scientific Director

Ulrika Yngve, Head of Unit

Johan Wannberg

Johanna Larsson

Lars Sandberg, computational chemist H2L unit



Medicinal Chemistry – Lead Identification

The Medicinal Chemistry – Lead Identification unit will take on, explore, and optimize molecules in drug discovery projects. Synthetic and computational chemistry will be at the core of the so-called Design-Make-Test-Analyze cycle that characterizes a small molecule drug discovery program. The mission is to deliver small drug-like molecules with potency, selectivity, physicochemical and ADMET properties of sufficient quality to allow proof-of-concept animal studies. We work in close collaboration with our colleges in the hit-to lead unit.

A technology development program on DNA-encoded libraries was initiated in 2018. A dedicated instrument park with a LC-MS for analysis of DNA-conjugated molecules as well as a preparatory LC and a gel electrophoresis system is available. The first SciLifeLab DNA-encoded library containing one million compounds is available for smailto:johan.wannberg@scilifelab.uu.seelections. To learn more about the project, contact Johan Wannberg.


  • Organic synthesis of bioactive compounds (small molecules and peptides).
  • Medicinal chemistry expertize.
  • Iterative design, synthesis and analysis of assay data to improve compound properties.
  • Compound characterization, structure determination and purity analysis.
  • Quantitative structure based activity relationships.
  • Scale-up synthesis of bioactive compounds.
  • Selection and purchase of commercial compounds.
  • Synthesis of reference compounds.
  • Competitive Intelligence
  • In collaboration with Medicinal chemistry Hit2Lead: Computer-based drug design


  • Analytical UHPLC-MS.
  • Automated flash chromatography systems.
  • GCMS instruments.
  • Hardware and software for Computer-Aided Drug Design.
  • Microwave batch reactors.
  • Microwave continuous flow reactors.
  • NMR spectrometers.
  • Peptide synthesizer.
  • Preparative HPLC instruments.

Using the unit

Please contact the Head of Unit, Ulrika Yngve.

Mailing Address

Uppsala University
SciLifeLab, BMC
Medicinal Chemistry – Lead Identification
Box 574
751 23 UPPSALA

Visiting Address/Deliveries

Uppsala University
SciLifeLab, BMC
Medicinal Chemistry – Lead Identification
Husargatan 3
751 23 Uppsala

Last updated: 2023-02-13

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