2018-10-17, NEWS

Selfish genes causing fungal fratricide

Selfish genes, genes that are passed on through generations without any benefit to the individual, are thought to be an important driver of evolution. With support from the National Genomics Infrastructure at SciLifelab, researchers at Uppsala University have sequenced two selfish genes found in the fungus Neurospora intermedia, both of which cause fungal spores to kill their siblings.

2018-10-17, NEWS

Enhanced validation of antibodies for research applications

There is a need for standardized validation methods for antibody specificity and selectivity. In this paper, the researchers show that the five pillars involving orthogonal methods, genetic knockdown, recombinant expression, independent antibodies and capture mass spectrometry analysis, can be used to validate antibodies for Western blot applications in a standardized and systematic manner. The study […]

2018-10-16, NEWS

Adiponectin proposed biomarker for detection of Metabolic Syndrome

The hormone adiponectin is put forward as a useful diagnostic indicator of Metabolic Syndrome following a meta-analysis of existing scientific data from more than 7 000 individuals. The study, led by Adil Mardinoglu (KTH/SciLifeLab), shows that lower levels of circulating adiponectin in blood are highly associated with increased occurrence of Metabolic Syndrome – defined as […]

2018-10-09, NEWS

New knowledge about retrovirus-host coevolution

Retroviruses have colonised vertebrate hosts for millions of years by inserting their genes into host genomes, enabling their inheritance through generations as endogenous retroviruses (ERVs). A study led by Patric Jern, Uppsala University/SciLifeLab  now provide new knowledge about the long-term associations of retroviruses and their hosts by studying ERV variation and segregation in wild and […]

2018-10-08, NEWS

Ancient genomes suggest western Iron Age nomads originate from eastern Pontic-Caspian steppe

A team of scientists led by Anders Götherström from Stockholm University has utilized the services of the SciLifeLab National Genomic Infrastructure (NGI) to investigate the demographic dynamics in the Pontic-Caspian steppe – stretching from the northern shores of the Black Sea as far east as the Caspian Sea. Sequencing of 35 genomes of Bronze Age […]

2018-10-08, NEWS

Two culture-independent strategies for recovering bacterial genomes both generate accurate information

A study enabled by Microbial Single Cell Genomics shows that single-amplified and metagenome-assembled genomes both  generate accurate genome information from uncultivated bacteria.  Prokaryotes dominate the biosphere and regulate biogeochemical processes essential to all life. Yet, our knowledge about their biology is for the most part limited to the minority that has been successfully cultured. Molecular techniques now […]

2018-10-03, NEWS

Three big grants from Knut and Alice Wallenberg foundation

Three research projects coordinated by researchers at SciLifeLab recently got support from the Knut and Alice Wallenberg foundation. Together, the projects were granted more than 90 million SEK. Project: ”Translating mechanisms of cytotoxicity in natural killer cells and gamma-delta T cells into next generation cell-based cancer immunotherapy” Grant: 31 200 000 SEK for five years Main […]

2018-09-28, NEWS

SciLifeLab opens its doors to the future generation of scientists

As part of the yearly event Researchers’ Night (ForskarFredag), SciLifeLab in Stockholm welcomed around 280 high school students on September 28. Scientists from our research community gave presentations on their fields of work, such as small molecules, supercomputers, and personalized medicine. To top it all off, the students were invited for a tour of a […]

2018-09-25, NEWS

New way of blocking DNA repair in cancer cells after radiation therapy

Half of all cancer patients will get radiation therapy at some point of their treatment. A research team led by Tomas Helleday, Karolinska Institutet/SciLifeLab, has found a new way of making cancer cells sensitive to radiation therapy. In the study, published din Nature Communications, the researchers show how they were able to block DNA repair […]

2018-09-21, NEWS

A new chemical probe for selective mass spectrometric analysis of the human gut microbiome

A new chemoselective metabolite modification technique for mass spectrometric investigation of metabolites in human samples has been developed by the laboratory of Daniel Globisch (Uppsala University/SciLifeLab). Application of this new multifunctional probe in human samples significantly improves mass spectrometric sensitivity and is a crucial tool for extending the scope of metabolomics research towards microbiota metabolism […]