2017-08-18, NEWS

New Pathology Atlas maps genes involved in cancer to accelerate personalized medicine

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine. In […]

2017-08-16, NEWS

Mapping of moose’s gut flora propels development of future biofuels

Through sequencing of ninety-nine moose stomach microbiomes, a study led by Anders Andersson (KTH/SciLifeLab) and Henrik Aspeborg (KTH) has provided new insights into microbial plant biomass degradation. The findings from the current project are highly relevant to the development of the second generation of biofuels. Using enzyme technologies converting forestland material into e.g. ethanol would offer […]

2017-08-10, NEWS

Ultrafast test for antibiotic susceptibility through single-cell imaging

A new study led by Johan Elf (Uppsala university/SciLifeLab) demonstrates that it is possible to determine in 30 minutes if a urinary tract infection is caused by antibiotics-resistant bacteria. Tailoring treatment against bacterial infections can help reduce unnecessary and incorrect use of broad-spectrum antibiotics, which aggravates the antibiotics resistance problem and poses a global threat to human health.  One way to […]

2017-08-09, NEWS

Receptor dynamics open up new possibilities for drug development

Novel findings reveal that G protein-coupled receptors, which have previously assumed to be statically configured as monomers or dimers, can switch between the two arrangements under different conditions. This provides new strategies for drug development, as separation or joining may be inhibited or triggered.    G protein-coupled receptors, a common type of protein in the […]

2017-08-08, NEWS

Childhood adiposity genes associated with risk for type 1 diabetes

A study led by Tove Fall (Uppsala University/SciLifeLab) shows that genetic variants associated with childhood body mass index (BMI) can be linked to the occurrence of type 1 diabetes. The results, published in PLOS Medicine, provides evidence that could be part of the explanation behind todays’s increased rates of type 1 diabetes.  Type 1 diabetes (T1D) rates have been increasing globally […]

2017-08-07, NEWS

Orientation of membrane proteins remains fixed

Membrane proteins are thought to attain their unique orientation very early, already when they are being produced. Flipping the pre-set orientations of proteins in the membrane was always believed to be an impossible process. However, recent studies have cast doubt on this view, causing a debate. Now, a paper published in PNAS, instead confirms the prevailing assumption that […]

2017-08-02, NEWS

Simple sugar reveals risk for type 2 diabetes and cardiovascular disease

A current study uncovers that measuring blood level of mannose, a simple sugar molecule that is part of many naturally occurring polysaccharides, can be used to forecast a person’s probability of developing type 2 diabetes, cardiovascular disease and progression of diabetic kidney disease.  The paper, authored by Adil Mardinoglu (KTH/SciLifeLab) shows that high basal levels of mannose predicts future […]

2017-08-01, NEWS

Blocking of enzyme halts brain tumour cell growth

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing. This is shown in a new study published in Molecular Cancer Therapeutics. Brain tumours constitute 25% of all childhood cancers. Among those are malignant forms such as medulloblastoma, a cancer of the cerebellum. Today, more […]

2017-08-01, NEWS

Long-lived sperms generate fitter offspring

Males produce hundreds of thousands to hundreds of millions of sperms in one single ejaculation, depending on the species. Does it matter which one that actually fertilizes the egg? A recent paper published in in PNAS reveals that selection of long-lived sperms from the male ejaculation results in offspring with greater prospects of surviving early […]

2017-08-01, NEWS

Innovative tool determines immune system differences in humans

Immune system function varies significantly between individuals, and up to now there has been no effective means of measuring and describing these differences. Now, a study led by Petter Brodin (Karolinska Institutet/SciLifeLab)  shows that white blood cell composition is unique in individuals, and that the composition of these cells may predict immune system responses. The […]

2017-08-01, NEWS

Novel method for studying bioavailability – a potential shortcut in drug development

A paper published in Proceedings of the National Academy of Sciences (PNAS) reveals a method for quantifying the intracellular bioavailability of drug molecules and thereby predict the drug’s access to intracellular targets as well as the resulting pharmacological effect.  Knowledge of the amount of drug that is available to bind targets inside cells provides a powerful tool for compound selection in early […]

2017-08-01, NEWS

New approach for virus RNA visualization can help predict pandemics

A recent paper published in Cell Reports presents a new technique for analyzing the whereabouts of influenza virus genetic segments in cells and tissues. The study, co-led by Mats Nilsson (Stockholm University/SciLifeLab) provides new strategies for evaluating how new mutations affect pathogenicity and identifying properties that enable or restrict influenza gene segment reassortment that give rise to to […]