2018-11-14, NEWS

The constraints of cyanobacterial growth

How is cyanobacterial growth constrained by abundance of light and CO2? A new study, led by SciLifeLab researcher Paul Hudson (KTH), delves deeper into the question. Using shotgun proteomics in the lab of Mathias Uhlén (KTH), also a SciLifeLab researcher, the group were able to examine the cyanobacteria proteome and how it reacted to variations […]

2018-11-13, NEWS

Oligodendrocytes suggested key players in development of multiple sclerosis

A recent study led by Gonçalo Castelo-Branco at Karolinska Institutet shows that oligodendrocytes, a cell type in the brain and spinal cord, might have a significant role in the development of multiple sclerosis (MS). The project was enabled by the National Genomics Infrastructure (NGI) and the National Bioinformatics platform (NBIS) at SciLifeLab.   2.5 million […]

2018-11-13, NEWS

How pneumococci evade the immune system

A novel study led by Birgitta Henriques-Normark at Karolinska Institutet sheds light upon how pneumococci inhibit immune reactions and survive inside human cells, causing pneumonia. Parts of the analyses were enabled by the Mass Spectrometry Based Proteomics facility of SciLifeLab. Pneumococci bacteria are found in the normal flora of healthy individuals of all ages, including […]

2018-11-08, NEWS

Japanese Business federation KEIDANREN visits SciLifeLab

The Japanese Business federation KEIDANREN, along with the newly appointed Japanese ambassador to Sweden, H.E. Shigeyuki Hiroki, visited SciLifeLab on Wednesday Nov 7 as part of KEIDANREN’s Mission to Sweden 2018. The mission is part of the ongoing 150th anniversary of diplomatic relations between Japan and Sweden. In addition to SciLifeLab, the delegation visited Ericsson, the Confederation […]

2018-11-05, NEWS

Online gamers and artificial intelligence to improve image classification

As reported back in 2016, Emma Lundberg’s research group has, by collaborating with the gaming company Massive Multiplayer Online Science, had their project about classification of protein images included in the online game EVE. EVE is played by over half a million people every month, meaning quite a few contributions to the group’s work – over 300 000 gamers played the game and generated 33 million protein image classifications.

2018-11-01, NEWS

Sixteen new Technology Development Projects (TDPs) announced

To contribute in keeping SciLifeLab infrastructure at cutting-edge, a call for Technology Development Projects (TDPs)was opened during spring 2018. Now the sixteen projects, which will receive a total of 40 MSEK over a two-year period, are revealed. The purpose of the TDP initiative is to enable the development, exploration and optimization of new technologies in […]

2018-10-31, NEWS

Mapping the genome of the Aspen tree

After almost ten years of work, an international team, lead by researchers at Umeå University and SLU, has sequenced the entire genome of the two species of Aspen trees. Mapping a species’ gene set is often considered the key piece of the puzzle in biology as, when it’s done, all sorts of studies can be performed. The mapping of the human genome made way for a broad range of breakthroughs in the 21st century’s medicine and hopefully, mapping the Aspen tree’s genome will lay a foundation for many future studies in the area.

2018-10-29, NEWS

Single-cell RNA sequencing reveals platinum chemotherapy resistance gene

An RNA sequencing study led by Per Uhlén from Karolinska Institutet identifies the gene COX7B to be associated with cancer cell resistance to platinum-based chemotherapy, such as cisplatin. The results also demonstrate that the membrane-associated protein CD63 may be used as a surrogate marker for platinum resistance. Knock-down of COX7B in cancer cells decreased the sensitivity […]

2018-10-17, NEWS

Selfish genes causing fungal fratricide

Selfish genes, genes that are passed on through generations without any benefit to the individual, are thought to be an important driver of evolution. With support from the National Genomics Infrastructure at SciLifelab, researchers at Uppsala University have sequenced two selfish genes found in the fungus Neurospora intermedia, both of which cause fungal spores to kill their siblings.

2018-10-17, NEWS

Enhanced validation of antibodies for research applications

There is a need for standardized validation methods for antibody specificity and selectivity. In this paper, the researchers show that the five pillars involving orthogonal methods, genetic knockdown, recombinant expression, independent antibodies and capture mass spectrometry analysis, can be used to validate antibodies for Western blot applications in a standardized and systematic manner. The study […]

2018-10-16, NEWS

Adiponectin proposed biomarker for detection of Metabolic Syndrome

The hormone adiponectin is put forward as a useful diagnostic indicator of Metabolic Syndrome following a meta-analysis of existing scientific data from more than 7 000 individuals. The study, led by Adil Mardinoglu (KTH/SciLifeLab), shows that lower levels of circulating adiponectin in blood are highly associated with increased occurrence of Metabolic Syndrome – defined as […]