News


2019-03-19, NEWS

Premature children shows adequate amount of maternal antibodies

In human newborns IgG antibody production starts 15 weeks after birth rendering them completely dependent on maternal antibodies transferred across the placenta during pregnancy, a phenomenon known as passive immunity. The concentration of maternal IgG in the fetus increases dramatically during the third trimester which has led to the belief that prematurely born children mostly […]

2019-03-11, NEWS

Genetic testing of colorectal cancer of low value before the age of 40

A study published in Molecular Genetics & Genomic Medicine concludes that the chance of detecting a hereditary cancer syndrome in young colorectal cancer patients is low. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). Colorectal cancer is the third most common cancer diagnosed in Sweden. Development of the disease before the age […]

2019-03-05, NEWS

SciLifeLab-AstraZeneca collaboration maps gene expression in heart failure

In the SciLifeLab/AstraZeneca collaboration on heart failure, a study has been published in Scientific Reports (https://rdcu.be/boOId) on mRNA expression in myocardial biopsies, obtained from patients undergoing elective coronary bypass surgery, as part of the large study named PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study). The study was led by SciLifeLab researcher Bengt Persson […]

2019-03-04, NEWS

Few genes involved in the wall lizard’s different traits

Different colored lizards of the same species differ in size, fighting ability and reproductive strategies – due to variation in only two genes, shows a study led by researchers from Uppsala University and the University of Porto. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). Reptiles show a diverse range of colors […]

2019-02-28, NEWS

New findings could help children with growth disorders

Researchers at Karolinska Institutet have discovered that bone growth in mice functions the same way new cells are being produced in blood, skin and other tissue – not a fixed number of “growing cells” that run out and we stop growing, as previously thought. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). […]

2019-02-27, NEWS

Portal to help interpret cancer data developed – first patients selected

The first patients have been selected for precision cancer therapy using the Molecular Tumor Board portal, a platform to support clinical decisions based on the genomics profile of the tumors. The Molecular Tumor Board portal is developed by researchers at Karolinska Institutet and SciLifeLab to help clinicians interpret biological cancer data and select the most […]

2019-02-26, NEWS

New skeletal disease uncovered

A group of researchers led by physician and Associate Professor Giedre Grigelioniene (Karolinska Institutet) have identified a previously unknown skeletal dysplasia. The study, now published in Nature Medicine, describes the molecular mechanism behind this rare condition. Their analyses were enabled by a SciLifeLab Clinical Genomics facility. A mother and her child had come to the clinic […]

2019-02-25, NEWS

More paternally expressed genes than previously thought

A recent study, published in Genome Biology, shows that there are substantially more paternally expressed genes in the endosperm of the plant Arabidopsis than what has previously been identified. This indicates that paternal-specific gene expression is of higher functional relevance than previous estimates. Genomic imprinting is an epigenetic phenomenon causing maternal and paternal alleles to […]

2019-02-22, NEWS

Evolution of common weed depends on parental legacy

A recent study led by Martin Lascoux (SciLifeLab/Uppsala University) shows how the evolutionary trajectory of a newly formed tetraploid species of plant closely depends on its parental legacy and on DNA presence from its diploid relatives. Most plant species have a polyploid origin, and many of them are allopolyploid species, which means that they originated […]