2018-08-17, NEWS

First genomic insights into prokaryotic endosymbioses from the archaeal domain of life

By studying the genomes of two endosymbiotic interactions between ciliates and methanogenic archaea, Thijs Ettema (Uppsala University/SciLifeLab) and colleagues have got the first insights into prokaryotic endosymbioses from the archaeal domain of life. Sequencing was performed by the National Genomics Infrastructure, NGI, at SciLifeLab. Endosymbiosis is the phenomenon of one organism living within the body or cells of another organism […]

2018-08-16, NEWS

Deciphering microbiota metabolism in humans

A new methodology for the selective mass spectrometric investigation of gut microbiota and human host co-metabolism has been developed by the laboratory of Daniel Globisch (Uppsala University/SciLifeLab). This investigation led to the discovery of a large number of previously unidentified metabolites and represents a tremendous potential for the identification of unknown mediators of disease development. […]

2018-08-15, NEWS

Novel method sheds light on cell development

Researchers at Karolinska Institutet and Harvard Medical School led by Sten Linnarsson (Karolinska Institutet/SciLifeLab) report in Nature that they have developed a technique to capture dynamic processes in single cells. The method can be used to study disease processes and to observe how specialized cell types are formed during embryogenesis. The new method is built on […]

2018-08-15, NEWS

New reversibly photoswitchable fluorescent protein for nanoscale imaging of living cells

Reversibly photoswitchable fluorescent proteins (rsFPs) are gaining popularity as tags for optical nanoscopy because they make it possible to image with lower light doses. However, green rsFPs need violet-blue light for photoswitching, which is potentially phototoxic and highly scattering. Ilaria Testa (KTH/SciLifeLab) and colleagues have developed new rsFPs based on the monomeric red fluorescent protein FusionRed, […]

2018-08-14, NEWS

Three SciLifeLab researchers receive ERC Starting Grants

Alexey Amunts, Tove Fall and Oskar Karlsson receive the prestigious Starting Grant from the European Research Council, ERC. Project funding amounts to up to 1.5 million euros each. The purpose of the ERC Starting Grant is to encourage talented young research leaders in Europe to become independent and build their own careers. This year, 403 […]

2018-08-14, NEWS

New insights in the mechanisms of chemical chaperone

Trimethylamine-N-oxide (TMAO) enables certain marine organisms to live under conditions that would otherwise destroy their cells, and can even protect unstable human proteins like the tumor suppressor p53. A new study by Michael Landreh, David Lane, Sonia Laín, (all at Karolinska Institutet/SciLifeLab) and co-workers, shows that TMAO acts like a shield against harmful proteins, pushing them […]