2017-10-18, NEWS

Four human genes connected to Obsessive Compulsive Disorder

The presence of several mutations in four important genes for the brain’s synapses can be associated to Obsessive Compulsive Disorder in humans. This is revealed through a study that included almost 600 patients and an about equal number of healthy controls. The investigations were led by Kerstin Lindblad-Toh (Uppsala University/SciLifeLab) in collaboration with a research team at Broad Institute, […]

2017-10-18, NEWS

Richer datasets from CRISPR/Cas9 screens using barcoded guide sequences

A novel study from researchers at Karolinska Institutet shows that by using so called random sequence labels, working as barcodes for tracing genetically altered cells, during CRISPR/Cas9 gene knock-outs it is possible to generate more comprehensive data from a smaller number of cells. The innovation has led to the SciLifeLab High Throughput Genome Engineering facility implementing barcodes in all future screening projects.  CRISPR/Cas9 gene […]

2017-10-17, NEWS

Facebook founder supports two SciLifeLab projects via global Human Cell Atlas effort

Two research projects based at SciLifeLab have been granted funding from the Chan Zuckerberg Initiative, which was formed by Facebook founder Mark Zuckerberg and his wife, Dr. Priscilla Chan, and provides financial and engineering support for the Human Cell Atlas – an ambitious international collaboration that aims to create a reference atlas of all cells in the healthy […]

2017-10-16, NEWS

Report on IAB evaluation of SciLifeLab available

The concluding report from the evaluation of SciLifeLab by the International Advisory Board (IAB) is now available (see below). It serves as a summary of the strategic evaluation performed by the IAB in March 2017 and provides feedback on several aspects of SciLifeLab operations to strengthen the development of the center. “The Science for Life […]

2017-10-05, NEWS

Electron microscopy technology offered at SciLifeLab gets awarded the Nobel Prize

On October 4, it was revealed that the 2017 Nobel Prize in Chemistry is awarded Jacques Dubochet, Joachim Frank and Richard Henderson for their development of cryo-electron microscopy (Cryo-EM) for the high-resolution structure determination of biomolecules in solution. Cryo-EM technology services is offered at SciLifeLab in Stockholm and Umeå as part of the national infrastructure resource. SciLifeLab Fellow (Stockholm University/SciLifeLab) Alexey Amunts and […]

2017-10-03, NEWS

Getting together

A big thank you to all of the SciLifeLab facility staff who met at our Facility Forum today to discuss important topics such as data management, teamwork and project models. Hopefully you also had the opportunity to network and get to know each other better. A special thank you to all of the staff who […]

2017-09-29, NEWS

Study presents how the ‘molecular scissors’ CRISPR-Cas9 search for specific DNA sequences

A study led by Johan Elf (Uppsala University/SciLifeLab) have demonstrated how the Cas9 component of the CRISPR-Cas9 genome editing technology is able to find the right DNA sequence. The results are published in Science magazine.  The CRISPR-Cas9 system has revolutionised biological research as it enables correcting or modifying essentially any DNA sequence. The hope is that these genetic scissors will […]

2017-09-29, NEWS

Genomic study reveals that modern humans emerged more than 300,000 years ago

A genomic analysis of ancient human remains from KwaZulu-Natal (South Africa) revealed that southern Africa has an important role to play in writing the history of humankind. The study was led by Mattias Jakobsson (Uppsala University/SciLifeLab) in collaboration with researchers from the Universities of Johannesburg and the Witwatersrand, South Africa. The team presents their results in the […]

2017-09-25, NEWS

NIH funding to Marcel den Hoed

Marcel den Hoed (Uppsala University/SciLifeLab) is a co-applicant of a project that was recently awarded a grant from the American NIH. The project will address the link between obesity and cardiometabolic complications and is a collaboration between researchers from USA, UK and Sweden. The project, led by Ruth Loos at Icahn School of Medicine at Mount […]