News - 2014
Focus on questions in bioimaging
On December 16 AIMday® Bioimaging brought together academic researchers, industrial representatives and clinicians for discussions on the exciting and rapidly developing field of bioimaging. As usual with the AIMday concept, questions and discussion topics from the industry were prepared beforehand and researchers signed up for the sessions that they found interesting, in order to provide […]
Science & SciLifeLab Prize winners visited Stockholm and Uppsala
In connection to the Science & SciLifeLab Prize for Young Scientists award ceremony at Grand Hotel in Stockholm, the winners visited SciLifeLab and participated in two symposia in Stockholm and Uppsala.
Joining the EIT Community
This week the European Institute of Innovation and Technology’s (EIT) announced the winners of the call for Knowledge and Innovation Communities (KIC) with focus on health.
New sequencing method can be used for clinical diagnostics of chronic lymphocytic leukemia
Today it is possible to use DNA sequencing to improve prognostication and predict treatment response in patients with the most common form of leukemia; chronic lymphocytic leukemia. New results from a research group lead by SciLifeLab faculty member Richard Rosenquist Brandell shows that next-generation sequencing technology can provide equally reliable results as previous methods. The […]
Smoking linked to loss of Y chromosome in men
In a new study, published in Science, researchers at Uppsala University and SciLifeLab demonstrate an association between smoking and loss of the Y chromosome in blood cells. The researchers have previously shown that loss of the Y chromosome is linked to cancer. Since only men have the Y chromosome, these results might explain why smoking is a greater risk factor for cancer among men and, in the broader perspective, also why men in general have a shorter life.
Winners of Science & SciLifeLab Prize for young scientists announced
The names of the four winners of this years’ Science & SciLifeLab Prize are now official. The grand prize of USD 25,000 goes to Liron Bar-Peled for his work describing how multicellular organisms rely on environmental cues to dictate cell size. The Science & SciLifeLab Prize for Young Scientists is a global prize, established in 2013 […]
SciLifeLab software tools are now open source
SciLifeLab recently launched an open source portal showcasing some of the research being done at the center. Open source code is released under a licence that allows others to use that code for their own purposes.
Academia and governmental authorities came together to explore the possibilities for collaboration on infectious disease control
As a part of SciLifeLab’s ambition to support and collaborate with governmental authorities SciLifeLab has, together with the National Veterinary Institute and the National Food Agency, organized a workshop on subtyping of pathogenic microorganisms using whole-genome sequencing. The aim of the workshop was to explore the requirements and possibilities to create a national network for microbial whole-genome sequencing.
Preliminary stage of blood cancer discovered – in healthy people
Researchers at Karolinska Institutet, KI, and SciLifeLab have together with colleagues in USA identified mutations in blood, which considerably increases the risk of developing various types of blood cancer, like leukaemia. The discovery, made by Johan Lindberg and Henrik Grönberg at KI/SciLifeLab among others, opens up new perspectives for research in the field of early […]
New method for rapid determination of antibiotic resistance
Scientists from SciLifeLab, Uppsala University and Uppsala University Hospital have developed a new method of rapidly identifying which bacteria are causing an infection and determining whether they are resistant or sensitive to antibiotics. The findings are now being published in the Journal of Clinical Microbiology.
New cancer therapy-company based on research from SciLifeLab
Chemical Biology Consortium Sweden (CBCS), a part of SciLifeLab, today announces the launch of a new biopharmaceutical company; Glionova Therapeutics, as a result of a collaboration with Patrik Ernfors, Professor at Karolinska Institutet.
Announcement of National Sequencing projects that will receive SciLifeLab funding
SciLifeLabs just approved the first 21 National Projects focused on human whole genome sequencing and biodiversity. In total, thousands of genomes will be sequenced within the projects.
Exploring and shaping the scientific conversation
Open science and science policy are two of Lynn Kamerlin’s favorite topics. Alongside her own research she is dedicated to advance not only science itself but also the way science is conducted. Research is a constant evaluation and reevaluation of models. Lynn Kamerlin is operating in one of the fields currently going through major changes, […]
The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing
Researchers at SciLifeLab have published a detailed study of the genomes of pediatric acute lymphoblastic leukemia (ALL) patients, together with pediatric oncologists from the university hospitals in Göteborg, Stockholm, Umeå and Uppsala.
Time to apply for bioinformatics support
Do you need an experienced bioinformatician in your project to analyse data? Bioinformatics Long-term Support (WABI) offers free support for at least 3 months effective time. Last day for application is November 21. More information and application form is found here.
Launch of the tissue-based map of the human proteins
A decade after the completion of the human genome, the Human Protein Atlas program today launched a tissue-based atlas covering the protein complement of the human genome. Based on 13 million annotated images, an interactive database has been created to show the distribution of proteins in all major tissues and organs in the human body.
New classification improves risk prediction in chronic lymphocytic leukemia
If chronic lymphocytic leukemia patients with a good or poor prognosis could be identified already at the time of diagnosis, physicians would have better possibilities to adjust their therapeutic and follow-up strategies. Now researchers at SciLifeLab, together with international colleagues, have discovered a new correlation between specific molecular features of the disease and subgroups of patients with different prognosis.
New money strengthens the Swedish bioinformatics infrastructure
The bioinformatics platform at SciLifeLab is expanding widely during 2015, not only in the Stockholm-Uppsala region but also to other universities. Thanks to extensive new funding a total of 12 new bioinformaticians will be recruited and a mentor program for PhD students will be launched.
New findings show that different brain tumours have the same origin
Glioma is a common name for serious brain tumours. Different types of glioma are usually diagnosed as separate diseases and have been considered to arise from different cell types in the brain. Now researchers at SciLifeLab have shown that one and the same cell of origin can give rise to different types of glioma.
Important mechanism that regulates sweating has been identified
Not being able to sweat can be fatal. But many also suffer from sweating too much. A group of researchers led by SciLifeLab faculty member Niklas Dahl have identified a key mechanism that regulates sweating. They are now using the results to develop a compound that could reduce sweat production for those people who suffer from unwanted and unhealthy sweating.
SciLifeLab reached out to Göteborg and Umeå
On October 14, representatives from SciLifeLab technical platforms visited Göteborg and Umeå to give an overview of what the center can offer. That the use of SciLifeLab technologies and expertise is almost free of charge thanks to the governmental financing was a pleasant surprise for many local researchers.
From barnacles to cholera
SciLifeLab Day October 2014 was a whole day event filled with cutting edge research, discussions and mingles. Many aspects of both health and environment was on the agenda.
They work with the Nobel Prize awarded microscopy techniques
The microscopy techniques developed by the three winners of the Nobel Prize in Chemistry 2014 is the corner stone at the Advanced Light Microscopy, ALM, facility at SciLifeLab. “These techniques constitute a paradigm shift in microscopy, truly worthy of the prize,” says Hjalmar Brismar, Professor at Karolinska Institutet/KTH Royal Institute of Technolgy and platform director at ALM.
From drop to ocean
Stefan Bertilsson studies microbial ecosystems in water and helps researchers to investigate the genetic material of single cells.
Wallenberg funding to excellent SciLifeLab-research
Two projects led by researchers at SciLifeLab have received funding from the Knut and Alice Wallenberg foundation. Researchers at SciLifeLab also participate in several other projects that received grants from the foundation.
SciLifeLab expands technology offer to Swedish researchers
SciLifeLab launches nine new national facilities available for Swedish researchers. The expertise in bioinformatics will be strengthened and specific investments will be made within single cell analysis, cryo electron microscopy and CyTOF-based techniques. In addition to the SciLifeLab host universities, Umeå University, Linköping University and Chalmers University of Technology will also contribute to these new facilities.
SciLifeLab receives funds for a new Illumina HiSeqXTen sequencing system
One of SciLifeLabs largest platforms is the National Genomics Infrastructure (NGI). In 2013 NGI performed more than 500 projects focusing on a wide variety of topics including human diseases and biodiversity. The projects were led by a large number of scientists from 11 Swedish universities and government agencies and have led to many high-impact publications.
Huge interest for SciLifeLab at Researchers Night
As part of the yearly event Researchers Night (ForskarFredag), SciLifeLab opened its doors for 250 high school students on September 26. “It was a super interesting day, I did not in any way expect that”, says one of the visiting students Nathalie Höri.
Uppsala Health Summit post-conference report
The conclusions from the SciLifeLab workshop on diagnostics and screening can now be read in the Uppsala Health Summit 2014 post-conference report.
They created an algorithm for studying bacterial genomes
Anders Andersson at KTH/SciLifeLab and colleagues have developed a new and unique method for studying the DNA from several bacterial strains at the same time. The method can be used to investigate the ecosystem in the Baltic sea or to understand how gut bacteria influence human health. The article was published in Nature Methods.
Lectures from Teachers Day
In collaboration with The Royal Swedish Academy of Science (Kungliga Vetenskapsakademien, KVA) SciLifeLab organized a Teachers day in May 2014. UR (Utbildningsradion) filmed all lectures, and September 11-12, 2014 the lectures are shown on Kunskapskanalen. After that the lectures will be available through UR Play.
Sequencing of five African fishes reveals diverse molecular mechanisms underlying evolution
In an effort to understand the molecular basis of adaptation in vertebrates, researchers sequenced the genomes and transcriptomes of five species of African cichlid fishes.
The genetic prehistory of the New World Arctic
The New World Arctic, the last region of the Americas to be populated by humans, has a relatively well-researched archaeology, but an understanding of its genetic history is lacking. SciLifeLab researchers present genome-wide sequence data from ancient and present-day humans from Greenland, Arctic Canada, Alaska, Aleutian Islands, and Siberia.
Study sheds light on how wild rabbits became tamed
The genetic changes that transformed wild animals into domesticated forms have long been a mystery. An international team of scientists has now made a breakthrough by showing that many genes controlling the development of the brain and the nervous system were particularly important for rabbit domestication. The study is published in Science and gives answers to many genetic questions.
Science and SciLifeLab Prize puts winner in the spotlight
In December 2014 the Science and SciLifeLab prize for young scientists will be awarded for the second time. For Daniel Streicker, the Grand prizewinner of 2013, wing the award has given him new collaborations, a larger research group and new forms of support from his current university.
Evolutionary history of honeybees revealed by genomics
In a study published in Nature Genetics, researchers from Uppsala University present the first global analysis of genome variation in honeybees.
Genetics and lifestyle have a strong impact on biomarkers for inflammation and cancer
In a new study published in Nature Communications, research scientists from SciLifeLab present for the first time a large-scale study of the significance of genetic, clinical and lifestyle factors for protein levels in the bloodstream.
Program for SciLifeLab Day, October 10, available
The Preliminary program for SciLifeLab Day October 10 is now available. Registration will open shortly so keep an eye on the webpage and the SciLifeLab Newsletter.
They fight rare and incurable muscle disease
Every year a few people are affected by Duchenne muscular dystrophy and face a difficult future. Muscular tissue in their bodies is slowly degraded, leading to decreased mobility, respiratory problems, heart failure and premature death. Mathias Uhlén and Cristina Al-Khalili Szigyarto at KTH/SciLifeLab have now hopefully taken a step closer to the development of new treatments for the disease.
New method showing cancer genes in microscope
Researchers from SciLifeLab have developed a new method to visualize gene defects that causes cancer. This method can help us to understand the development of cancer and improve future cancer diagnostics.
Why white dogs are white
About half of all dogs show some form of white spotting which can range from a few white marks in the Bernese mountain dog to extreme white coat color in Dalmatians and white boxer. But why have dogs so often white markings, and how can we explain how they are determined genetically? This has researchers from SciLifeLab spread new light on in an article that is now published in the scientific journal PLoS One.
SciLifeLab members ranked among the world’s leading scientific minds
The media and information firm Thomson Reuters has done a citation analysis report to find out who the world’s most influential scientific minds are 2014. Four researchers on this list are SciLifeLab Faculty members.
SciLifeLab researchers win protein structure competition
A research group at SciLifeLab, led by Jens Carlsson, has won a worldwide competition to predict the three-dimensional structure of a G protein-coupled receptor using computer modeling. Their results are published in two articles in the scientific journal Structure.
New assay for point of care applications
In an article published in Clinical Chemistry Helene Andersson Svahns group at SciLifeLab/KTH Royal institute of technology present a new, inexpensive and rapid tool that can detect at least 1 480 molecular biomarkers at the same time. It is a paper based vertical flow microarray assay that could find use in future point of care affinity proteomic applications, for instance in the fields of autoimmunity, allergy, infection or cancer diagnostics.
SciLifeLab is recruiting
We are currently announcing several high profile positions within our community. One of them being a new Director for the Drug Discovery and Development platform positioned in Uppsala. Eight SciLifeLab Fellows positions as research leaders are available and SciLifeLab also announces the position of a new scientific leader (Director) for SciLifeLab from July 2015.
SciLifeLab is looking for a new Director
A new Director will be recruited to SciLifeLab from July 2015. The new scientific leader will take over the responsibility from Professor Mathias Uhlén who will leave his post after almost six successful years.
Genes make crows choose partners that look alike
Crows like to select mates that look alike. In a large-scale genomic study, published in Science today, a team of researchers led by Uppsala University found that this behaviour might be rooted in their genetic make-up, revealing a likely common evolutionary path that allows for separating populations into novel species.
The Drug Discovery and Development platform important part of upcoming research school
Hello Per Arvidsson, Platform Director at the Drug Discovery and Development platform at SciLifeLab which will play an important role in the upcoming Vinnova sponsored research school in Drug Discovery & Development:
Costs and benefits of diagnostics and screening
An ageing population is one of the major challenges of present and future healthcare. During two days researchers and industry will meet with other experts and decision makers in healthcare to share thoughts and insights on this matter.
Inspiration day for teachers in collaboration with The Royal Swedish Academy of Sciences
May 13 SciLifeLab hosted an inspiration day for teachers in collaboration with The Royal Swedish Academy of Sciences (KVA) on the topic Challenges and possibilities in medical research. Lectures were given by Kerstin Lindblad-Toh, Åsa Melhus, Adam Ameur, Eva Molin, Ulf Gyllensten and Marie Allen. All lectures were very much appreciated by the approximately 20 […]
Loss of Y chromosome can explain higher cancer risk and shorter life expectancy for men
It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by SciLifeLab researchers at Uppsala University, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.
Blood test could save lives of malaria-patients
According to the World Health Organization (WHO) 627 000 people died from malaria in 2012. Most of them were children younger than five years old. Researchers at KTH Royal Institute of Technology and SciLifeLab have now, together with colleagues in England and Nigeria, found a way to differentiate patients with a lighter form of the disease from those who develop more severe and deadly forms of malaria.
The Gamma house inaugurated
On April 10 the new SciLifeLab building in Solna was inaugurated. The Vice Chancellors of the three Stockholm universities cut the ribbon to the new 6 000 square meters of office and laboratory space.
SciLifeLab Day great success
More than 800 researchers, students and industry representatives from all over Sweden gathered in Aula Medica in Stockholm to listen to exciting research seminars on April 10. “It is amazing to see how life science research has evolved in the Stockholm-Uppsala region and how nice different disciplines have been put together by SciLifeLab ” said Janet Thornton, EMBL UK, who was one of the days keynote speakers.
The tying of strings
Today the new building Navet was inaugurated in Uppsala. Among the speakers were Minister Jan Björklund, Vice-chancellor Eva Åkesson and Co-director Kerstin Lindblad-Toh, who also tied two green strings together to symbolize the coming together and creating bonds, which is the core of SciLifeLab. The mingle and the ceremony was well visited and among other […]
New tool for the understanding of gene evolution
Jens Lagergren, Professor at KTH Royal Institute of Technology/SciLifeLab, has together with his colleauges developed a new method for mapping the evolution af genes over time. Their work is presented in Systematic Biology.
Researchers at SciLifeLab find new general concept for cancer treatment
A team of researchers from five Swedish universities, led by Thomas Helleday at Karolinska Institutet/SciLifeLab, have identified a new way of treating cancer. The study, which engaged 45 researchers at SciLifeLab, was presented in the journal Nature.
Mats Nilsson appointed Site Director for SciLifeLab in Stockholm
The Vice Chancellors of Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University have appointed Mats Nilsson Site Director for SciLifeLab in Stockholm. He started his duties 1 April 2014.
Cause of unusual bone tumour found
Tomuors originating from the skeleton are unusual and it is difficult to part malignant tumours from ones that won’t spread. Researchers from Lund University and Stockholm University/SciLifeLab have now found a genetic change that causes the benign tumour forms. This new knowledge can make it easier for physicians to give a precise diagnose and by that save some patients the suffering of an unnecessarily tough treatment. The study was published in Nature Genetics.
New approach makes cancer cells explode
Researchers at Karolinska Institutet and Uppsala University have discovered that a substance called Vacquinol-1 makes cells from glioblastoma, the most aggressive type of brain tumour, literally explode. When mice were given the substance, which can be given in tablet form, tumour growth was reversed and survival was prolonged. The study was partly performed at the national platform Chemical Biology Consortium Sweden (CBCS) at SciLifeLab. The findings are published in the journal Cell.
Supporting bioinformatic research all over Sweden
By entering different research groups for a time, Anna Johansson shares her expertise with the whole research society.
SciLifeLab opens call for national projects
SciLifeLab now welcomes applications for the first national research projects, based on next generation DNA sequencing. The projects focus on two areas: whole genome human DNA sequencing to study the genetic basis of disease, and studies related to biodiversity.
Starting on Thursday March 6 at 10:00-11:00 there will be a SciLifeLab Bioinformatics Drop-in for researchers wanting to discuss bioinformatics problems with experts from SciLifeLab. The “drop-in” will take place every Thursday at 10:00-11:00, at the third floor (E10:3) in Navet, the new SciLifeLab building at BMC in Uppsala.
Time to apply for the Science & SciLifeLab Prize 2014
Are you a newly awarded PhDs in Cell and Developmental Biology, Genomics and Proteomics, Environment, or Translational Medicine? Then you should apply for this years’ Science & SciLifeLab Prize for Young Scientists. The grand prizewinner from each category will receive USD25,000.
Mapping of Baltic Sea microorganisms will create models for climate changes
Although we know that sea microorganisms play an important role for marine life our knowledge about them has been very limited until recently. In a large scale mapping of the Baltic Sea, researchers from Stockholm University and SciLifeLab have now identified 22 million genes in viruses, bacteria and plankton. Understanding of how microbes are distributed in the sea can hopefully be used to provide future models for climate changes.
SciLifeLab joins the Illumina Genome Network
SciLifeLab has joined the Illumina Genome Network (IGN) to provide researchers with broader access to Illumina’s whole genome sequencing technology. SciLifeLab is the first IGN partner in Europe and will initiate a national large-scale population sequencing program seeking to identify genetic causes of human diseases.
Obsessive Compulsive Disorder dogs serve as model for the disorder in humans
Researchers at SciLifeLab have identified four genes connected to obsessive compulsive disorder (OCD) in dogs. The results, which will be published in the next issue of Genome Biology, could introduce new paths for research into human OCD.
Time to apply for WABI-support
A senior bioinformatician will work in your project 6-12 months for free!
New release of the InParanoid ortholog database
A new version of the InParanoid ortholog database, developed at SciLifeLab and Bioinformatics Infrastructure for Life Sciences (BILS) has been released online.
DNA gold threads close electrical circuits in biosensors
By letting DNA strands grow together with gold, scientists at Uppsala Berzelii Centre for Neurodiagnostics and Science for Life Laboratory have developed a brand new concept for super sensitive diagnostics of different diseases. The study will be published in the upcoming issue of ACS Nano.
ERC-grant to SciLifeLab researchers
Helene Andersson Svahn and Johan Elf have been granted EUR 4.4 together from the European Research Council, ERC.
Small drops speeds the production of industrial enzymes
Researchers at SciLifeLab have shown that a high-throughput method using microfluidic droplet sorting of mutated yeast cells can be used to improve the production of industrial enzymes.
Precall for national research projects
In the beginning of 2014, SciLifeLab will welcome applications for the Swedish 1,000 Genomes and the Swedish Biodiversity programs. These two national programs, which will run throughout 2014 and 2015, are based on massively parallel sequencing using the National Genomics Infrastructure and will allow Swedish scientists to carry out internationally competitive research.