News - 2015
A horse of a different colour: genetics of camouflage and the Dun pattern
Most horses today are treasured for their ability to run, work, or be ridden, but have lost their wild-type camouflage: pale hair with zebra-like dark stripes known as the Dun pattern. Now an international team of scientists has discovered what causes the Dun pattern and why it is lost in most horses. The results, published […]
Tjugo spännande projekt går på djupet med arvsmassan
Hur påverkar omgivningen en amöbas förmåga att göra människor sjuka, och hur ser arvsmassan ut hos svampar som bryter ner skräp? Tjugo forskningsprojekt inom hälsa och miljö får stöd av SciLifeLab för att sekvensera över 3000 hela arvsmassor.
Dogs split off from wolves in Asia 33,000 years ago
The origin of dogs has inspired a lingering controversy in academia. Peter Savolainen, KTH Royal Institute of Technology/SciLifeLab, recently published a study in Cell Research that he hopes will finally settle the matter. Read full news article
EU-commissioner visited SciLifeLab
On December 10th the EU-commissioner for Research, Science and Innovation, Carlos Moedas, and Swedish Minister for Higher Education and Research, Helene Hellmark Knutsen, visited SciLifeLab in Stockholm. The ministers were given an overview of the center by Chairman of the Board, Carl-Henrik Heldin, and Director Olli Kallioniemi. They were also given a tour of the labs […]
Mathias Uhlén leads new protein center
A new center for protein research, Wallenberg Centre for Protein Research (WCPR), will be established at KTH Royal Institute of Technology in the beginning of 2016. The center will be led by former Director and current faculty of SciLifeLab, Mathias Uhlén. The research at WCPR will focus on human proteins and development and production of biopharmaceuticals […]
Novel method for enzyme engineering developed at SciLifeLab
Per-Olof Syren, KTH Royal Institute of Technology/SciLifeLab, and his colleagues have discovered a new strategy for designing enzymes using water as enzyme building blocks. By rebuilding the enzyme so that water fits in the protein backbone, they created a stronger interaction between the enzyme and its substrate. Their work shows that the incorporation of water […]
Breast cancer dependent on cell cooperation to grow
– discovery awarded international science prize Researcher Allison Cleary has, for the first time, demonstrated that different types of tumor cells cooperate in the development and growth of breast cancer. For these findings, she is awarded the Science & SciLifeLab Prize for Young Scientists and thereby receives 30,000 USD as well getting published in Science […]
She is grand prize winner of Science & SciLifeLab Prize 2015
For the first time ever Allison Cleary has shown that different clones of tumor cells cooperate to make breast cancer tumors grow. For this discovery she is awarded Science & SciLifeLab Prize for Young Scientists and receives 30,000 USD and a publication in Science. Press release in English Infographic in English Pressrelease in Swedish Infographic […]
Blood test reveals how old your body really is
Now a simple blood test can reveal your biological age—how old your body really is. This was found in a new study from SciLifeLab/Uppsala University, the results of which are now being published in the open-access journal Scientific Report (Nature Publishing Group).
Excellent development in short time – SciLifeLab gets good grades from the Swedish Research Council
For the first time ever SciLifeLab has been subject to a public evaluation by the Swedish Research Council on behalf of the Swedish government. The experts’ opinion is that SciLifeLab is an impressive investment with good possibilities to become a world-leading center.
Alexey Amunts awarded Microscopy Society of America prize
The microscopy Society of America annually recognizes preeminent scientists from Biology and Physics, who have made distinguished contributions to the field of microscopy and microanalysis. The 2015 prize in Life Sciences was awarded to Alexey Amunts, Assistant Professor at Stockholm University / SciLifeLab. The rewarded work showed that electron cryo-microscopy (cryo-EM) can achieve visualization […]
Cannabinoid receptors could be targeted to fight liver cancer
A scientific article published in Cell Reports show that blocking the body’s cannabinoids might be an effective treatment for patients with liver cancer. SciLifeLab researchers Mathias Uhlén (KTH Royal Institute of Technology), Jens Nielsen (Chalmers University of Technology) and newly recruited fellow Adil Mardinoglu (KTH Royal Institute of Technology) all contributed to the findings together with others. […]
Focus on Diagnostics and Biomarkers
On November 18, AIMday® Diagnostics & Biomarkers in Uppsala brought together academic researchers, industrial representatives and clinicians for discussions on this important and exciting subject. The AIMday concept is based on questions and topics from the industry that are prepared beforehand. Researchers will then sign up for sessions where they can offer their expertise. Several […]
A ’supergene’ underlies genetic differences in testosteron levels and sexual behaviour in male ruff
The ruff is a Eurasian shorebird that has a spectacular lekking behaviour where highly ornamented males compete for females. Whole genome sequencing has now revealed that males with alternative reproductive strategies carry a chromosomal rearrangement that has been maintained as a balanced genetic polymorphism for about 4 million years. The chromosomal rearrangement (an inversion) has […]
Why combined therapies increase survival in prostate cancer
Researchers at Karolinska Institutet, SciLifeLab and Centre for Clinical Research, Västerås have been able to explain why a combination of castration therapy and radiation therapy increases survival rates for patients with prostate cancer, compared to if they only receive radiation therapy. The findings, which are presented in the journal Science Translational Medicine, show that castration […]
Early contact with dogs linked to lower risk of asthma
Tove Fall is Assistant Professor in Epidemiology at the Department of Medical Sciences, SciLifeLab/Uppsala University. Foto: Mikael Wallerstedt A team of Swedish scientists have used national registries encompassing more than one million Swedish children to study the association between early life contact with dogs and subsequent development of asthma. This question has been studied extensively […]
World’s largest protein array printed at SciLifeLab
Protein fragments representing 94% of the human proteome has been printed on two glass slides at SciLifeLab’s facility Protein and Peptide Arrays making it the largest array ever printed world wide.
Gut bacteria play key role in body’s self-defense
A new study reveals that human intestinal flora regulate the levels of the body’s main antioxidant, glutathione, which fights a host of diseases. The findings were published in Molecular Systems Biology and could lead to new probiotic-delivering foods, and a better understanding of the metabolic processes behind diseases such as type 2 diabetes. One of the researchers […]
Drop-in support at Bioinformatics
Are you planning a project and need someone to discuss the bioinformatics analysis with? Do you need bioinformatics support, but do not know who to turn to? Are you stuck in your own bioinformatics project and need help? Now experts from the SciLifeLab Bioinformatics platform/BILS/WABI are at your disposal every Tuesday at 10:30 at the Stockholm […]
Planting a famous spruce
Today a very special spruce was planted in the Botanical Garden in Uppsala. In 2013 researchers mapped the gene sequence of Norway spruce (the Christmas tree). It was the largest genome to have ever been mapped and the project was led by Umeå Plant Science Centre and SciLifeLab. This was a milestone in many […]
Lost and found in life science
This fall’s SciLifeLab Day offered a number of new concepts. Interactive workshops and four-minutes research presentations mingled with traditional talks on frontline research. Over 500 participants attended the two-day event. SciLifeLab’s technologies and services – how to use them and how they should develop – were discussed in different formats. One service offered on […]
Apply for Bioinformatics Long-term Support
One of the national services offered by SciLifeLab is long-term bioinformatics support in next generation sequencing and related omics. The idea is simple: A senior bioinformatician will work in your project for 500 hours and the costs are covered by the SciLifeLab Bioinformatics Platform. To get support, you need to submit a small application about […]
A new dimension to human whole genome sequencing
One of SciLifeLab’s research groups is the first site in Europe to obtain the new Gemcode system for phasing short-read DNA sequencing data. It has recently become possible to sequence whole human genomes at a reasonable cost using next generation DNA sequencing based on short-read technology. The recently launched Gemcode system adds a new dimension […]
New method to predict increased risk of breast cancer
By detecting cancer at an early stage, or even predicting who has an increased risk of being affected, the possibilities to treat the disease can be radically improved. In an international study led from SciLifeLab/Uppsala University the researchers have discovered that apparently healthy breast cells contain genetic aberrations that can be associated with an increased […]
Highly Cited SciLifeLab Researchers 2015
The media and information firm Thomson Reuters has done their yearly citation analysis report to find out who the world’s most influential scientific minds are 2015. On the list are the two SciLifeLab Faculty members Mia Wadelius and Erik Sonnhammer. Also on the list is Sören Brunak, member of SciLifeLab’s International Advisory Board, and Göran […]
Sleep regulating proteins involved in DNA repair
Researchers at Karolinska InstitutetKarolinska Institutet/ScilLifeLab and the University of Hong Kong has found a molecular mechanism for DNA repair where the protein PARP-1 in an unexpected way interacts with sleep regulating proteins in humans. The study, led by Thomas Helleday at Karolinska Institutet/ScilLifeLab is presented in Molecular Cell.
Nominate your favourite speaker
SciLifeLab The Svedberg Seminar series is a distinguished speaker series within the field of biosciences and holds research seminars given by leading scientists from Sweden and worldwide. SciLifeLab The Svedberg committee now invites you to nominate speakers of your interest. This is an excellent opportunity for your research group and students to extend their network and engage in scientific […]
Researchers show that genetic background regulates tumour differences
Researchers from SciLifeLab/Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumour type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients. This novel finding could lead to a better understanding for how varied genetic background influences the differences […]
Increased governmental funding for SciLifeLab 2016
The Swedish Government proposes an increase in SEK 50 million to SciLifeLab during 2016.
New Site director in Uppsala
September 16, a new Site director was appointed by Eva Åkesson, Vice-chancellor at Uppsala University. Johan Elf has been appointed Site director at the Uppsala node until June 30, 2016. He is part of the national management group, together with the Director, Co-director, Site director in Stockholm, and the Platform director. He replaces Lena Claesson-Welsh, […]
Promoting young researchers in synthetic biology
Uppsala Genome Center supports the Uppsala University student team during the synthetic biology competition iGEM.
New acting Co-Director for SciLifeLab
The board has appointed Lena Claesson-Welsh acting Co-Director for SciLifeLab. Lena Claesson-Welsh, who previously served as the director for the SciLifeLab regional platform BioVis (Biological Visualisation) facility, has been a member of the SciLifeLab management since July 1st.
Ancient genomes link early Iberian farmers to Basques
An international team led by researchers at SciLifeLab/Uppsala University reports a surprising discovery from the genomes of eight Iberian Stone-Age farmer remains. The analyses revealed that early Iberian farmers are the closest ancestors to modern-day Basques, in contrast previous hypotheses that linked Basques to earlier pre-farming groups. “Our results show that the Basques trace their […]
Genetics provides novel insights into evolution
Professor Anna Qvarnström is one of the many researchers who use SciLifeLab. Read about her exciting endevour to reconstruct millions of years of speciation using modern genetic techniques.
The Subcellular Protein Atlas featured in Nature Methods
Emma Lundberg, KTH/SciLifeLab, is interviewed in the September issue of Nature Methods. The article gives an overview on techniques that are used to locate proteins within cells and Emma Lundberg shares her experiences from her work with the Subcellular Protein Atlas within the Human Protein Atlas, HPA.
SciLifeLab symposium at Kunskapskanalen
14:00 on Thursday, September 10, a seminar series about women in science will start to broadcast at Kunskapskanalen. The seminars have been recorded at the SciLifeLab symposium Pathways to Excellence.
Study reveals the genetic start-up of a human embryo
An international team of scientists led from Sweden’s Karolinska Institutet has for the first time mapped all the genes that are activated in the first few days of a fertilized human egg. The study, which is being published in the journal Nature Communications , provides an in-depth understanding of early embryonic development in human – and scientists now hope that the results will help finding for example new therapies against infertility.
New mechanism discovered behind infant epilepsy
Scientists at Karolinska Institutet/SciLifeLab and Karolinska University Hospital in Sweden have discovered a new explanation for severe early infant epilepsy. Mutations in the gene encoding the protein KCC2 can cause the disease, hereby confirming an earlier theory. The findings are being published in the journal Nature Communications.
PhenoMeNal: a gateway to personalised medicine
The EU-funded project PhenoMeNal is launched today. It is led by EMBL-EBI with the purpose of creating a secure, on-demand e-infrastructure for clinical metabolomics data. Today marks the launch of PhenoMeNal, a project to create an e-infrastructure to analyse metabolomic data from clinical and population studies. An international endeavour led by EMBL-EBI, PhenoMeNal is funded […]
New biobank resource for research on brain tumors
In the latest issue of the magazine EBioMedicine researchers at SciLifeLab/Uppsala University present a biobank with cell lines that can be used as models for brain tumors. The biobank and its database with information about the cells is a resource that can be used by researchers all over the world. Read the full news article […]
Picoliter droplet screening system finds more productive yeast cells
A recent paper in the Proceedings of the National Academy of Sciences (PNAS) describes how researchers at KTH/SciLifeLab were able to find more productive yeast and the underlying genetic alterations using picoliter droplet screening in a microfluidic system.
New candidate genes for immunodeficiency identified
IgA deficiency is one of the most common genetic immunodeficiency disorders in humans and is associated with an insufficiency or complete absence of the antibody IgA. Researchers led from SciLifeLab/Uppsala University and Karolinska Institutet in Sweden have now performed the first comparative genetic study of IgA deficiency by using the dog as genetic disease model. […]
Call for proposals for development projects
The Steering group of SciLifeLab in Stockholm now opens a call for projects aiming to develop concepts for future SciLifeLab facilities.
New method for DNA analysis published in Nature Communications
A research group from the Royal Institute of Technology (KTH) at SciLifeLab has developed a method for parallel analysis of millions of single DNA molecules, presented in the June issue of Nature Communications. The method enables use of widely available short-read DNA sequencing platforms to study long single molecules within a complex sample, without losing information of physical connection between sequencing reads from each molecule of origin.
Lena Claesson-Welsh recruited to the SciLifeLab management
Starting July 1st, Lena Claesson-Welsh will be the first Site Director for SciLifeLab in Uppsala. As part of the SciLifeLab management she will play an important role in the future development of the center.
Stefan Ståhl appointed acting Platform Director
KTH Royal Institute of Technology has appointed Stefan Ståhl acting Platform Director at SciLifeLab until the permanent position has been assigned.
New chair for SciLifeLab
The Swedish government has appointed Carl-Henrik Heldin new chair for SciLifeLab, starting October 1, 2015. He succeeds Göran Sandberg who resigns on his own request after two years on the post.
New mechanism for male infertility discovered
A new study led from SciLifeLab links male infertility to autoimmune prostatic inflammation. The findings are published in the journal Science Translational Medicine. Involuntary childlessness is common, and in half of all cases attributable to infertility in the man. Although male infertility has many possible causes, it often remains unexplained. In the present study, the […]
New, robust and inexpensive technique for protein analysis in tissues
A new technique to study proteins, which does not require advanced equipment, specialized labs or expensive reagents, has been developed at SciLifeLab/Uppsala University. The technique could be further developed to be used in point of care devices, for instance for diagnostic purposes. SciLifeLab Faculty members Ola Söderberg and Masood Kamali-Mogaddam and their research teams have […]
New zebrafish CRISPR/Cas9 technology available at SciLifeLab
The zebrafish facility at SciLifeLab has participated in the development of a high-throughput gene targeting method in zebrafish, presented in the July issue of Genome Research. The technology is now offered as a service for Swedish researchers.
XYZ – inside the interface between system and reality
The always changing art piece XYZ hangs in the air above the meeting square in Navet. It plays with our notion of collecting data in our constant quest of measuring our world.
Discussions on a world without antibiotics
Uppsala Health Summit invited decision makers, opinion leaders and experts to meet this week to discuss consequences of actions and of non-actions for people, animals and the planet – all in the light of antibiotics. This year’s Uppsala Health Summit has come to an end. The two day long program has been filled with […]
Extensive study of five-year mortality risk
Researchers from SciLifeLab/Uppsala University have studied the risk of dying over the next five years. They have developed a unique health-risk calculator by using one of the world’s largest study material, UK Biobank, containing data from nearly half a million people. The results are expected to have large areas of application both in the clinical […]
New SciLifeLab management
The center management will be reorganized from July 1st, 2015.
SciLifeLab widens its infrastructure capacity
SciLifeLab strengthens its available infrastructure and offers further support to Swedish researchers with activities at universities in Gothenburg, Linköping, Lund and Umeå.
Open doors at SciLifeLab in Uppsala
The first SciLifeLab Open House drew hundreds of visitors to the six SciLifeLab campuses in Uppsala. All facilities held their own open sessions and visitors were also welcome to get a guided tour of Navet, the SciLifeLab meeting place at Uppsala Biomedical Centre (BMC). The day ended with a mingle with ample time for […]
Women’s pathways to academic excellence
Photo: Frozentime On May 22, a large number of prominent women from academic institutions in Europe and the US met in Uppsala to share their experience and knowledge about pursuing an academic career as a woman. The first speaker was Eva Åkesson, Vice-chancellor at Uppsala University. She began her talk by observing that the […]
No genetic trace of colonisers’ pets in Madagascan dogs
In his latest research on the origins of dogs around the world, Peter Savolainen, KTH Royal Institute of Technology/SciLifeLab, set out to examine the genetic connection between dogs in Madagascar and the pets of ancient settlers from Indonesia. But to his team’s surprise, no trace of Indonesian ancestry could be found among Madagascan dogs.
Belgian shepherd dogs seem to have genetic protection against diabetes
A genetic interaction which may protect Belgian shepherd dogs from developing diabetes has been discovered in a project led by researchers from the Swedish University of Agricultural Sciences and SciLifeLab/Uppsala University. In this breed, the researchers found a novel mechanism of regulating blood sugar levels via an interaction of genes located on two different chromosomes. […]
Mutation affecting cell signalling in chronic lymphocytic leukemia identified
To gain a better understanding of the development of chronic lymphocytic leukemia, researchers at SciLifeLab/Uppsala University have studied a specific signalling pathway that affects the growth of tumour B-cells. They identified a signalling protein that was frequently mutated in more aggressive subsets of the disease. This mutation was also detected in other B-cell malignancies, thereby […]
Health, chemistry and early drug development
The reoccurring theme of Mats Larhed’s work is the improvement of human health. It is reflected in both his effort on developing new drug candidates and in his coordination of the EU health project EIT Health in Uppsala. Mats Larhed has just returned to work from a trip to Norway where he has […]
Researchers discover missing link in the evolution of complex cells
In a new study, published in Nature this week, a research team led from SciLifeLab/Uppsala University presents the discovery of a new microbe that represents a missing link in the evolution of complex life. The study provides a new understanding of how, billions of years ago, the complex cell types that comprise plants, fungi, but […]
SciLifeLab deemed as an excellent strategic research environment
Both nodes of SciLifeLab received excellent grades in all three categories by the Swedish Research Council in their evaluation of the Strategic Research Areas (SRA). SciLifeLab encompasses two Strategic Research Areas (SRAs), one at KTH Royal Institute of Technology (MolbioKth) and one at Uppsala University (MolbioUu). In the evaluation presented on May 1 both SRAs […]
New insights into silencing of parasitic DNA elements and genomic stability
A study led by newly recruited faculty Simon Elsässer at Karolinska Institutet/SciLifeLab shows that a specialized histone protein, one of the abundant molecules responsible for compacting our DNA in the cell nucleus, maintains genomic stability by silencing ‘parasitic’ DNA-elements. The study was published in Nature.
Full house on SciLifeLab Day in Stockholm
Once again SciLifeLab Day filled Aula Medica at Karolinska Institutet when 740 attendees came to learn more about the center.
How bee queens avoid inbreeding
A research group lead by Matthew Webster, SciLifeLab/Uppsala University, has discovered how honeybees avoid inbreeding. One of the key factors is extreme recombination. Read the full press release (in Swedish)
Annual report 2014
The SciLifeLab annual report 2014 is here! Read about what we accomplished last year including scientific highlights, platform- and facility presentations and interviews with members of the board, SAB and NRC.
Extended application deadline for national projects
The deadline for application to the National projects has been extended to May 15, 2015. An additional call might follow later depending on the outcome of the second call. For more information contact: firstname.lastname@example.org or Karin Dahlman-Wright (Karin.Dahlman-Wright@ki.se).
New biomarker for uterine cancer discovered
Researchers at SciLifeLab/Uppsala University have, together with researchers from Turku and Bergen, discovered a new biomarker which makes it possible to identify women with uterine cancer who have a high risk of recurrence. The findings were recently published in the journal Gynecologic Oncology. – I view the results as a first step towards personal treatment […]
New research committee
The Swedish government has appointed a new research committee. Kerstin Lindblad-Toh, Co-Director at SciLifeLab, is one of the committee members. Read the full announcement (in Swedish)
Nominate your favourite speaker
SciLifeLab The Svedberg Seminar series is a distinguished speaker series within the field of biosciences and holds research seminars given by leading scientists from Sweden and worldwide. SciLifeLab The Svedberg committee now invites you to nominate speakers of your interest. This is an excellent opportunity for your research group and students to extend their network and engage in […]
New director at the Drug Discovery and Development platform
SciLifeLab has recruited Kristian Sandberg as Director of the Drug Discovery and Development platform. His most recent position was at AstraZeneca where he validated new targets for the company project portfolio.
SciLifeLab researchers awarded with the Göran Gustafsson Award
Two SciLifeLab researchers are awarded with the prestigious Göran Gustafsson Award. The Göran Gustafsson Award is Swedens biggest national award in molecular biology. The award is divided into five categories: mathematics, physics, chemistry, molecular biology and medicine. Two of the five winners in 2015 are faculty at SciLifeLab. Mattias Jakobsson, at SciLifeLab and Uppsala University, […]
In order to raise awareness of the technologies and expertise offered to researchers from all of Sweden, SciLifeLab organized a national outreach day in Lund and Linköping on March 19. Several of the platforms presented their offer and organized workshops. Ample time was put into discussion and answering of questions regarding the services at the […]
Evolutionary novelties in vision
A new study from SciLifeLab/Uppsala University published in PLOS ONE shows that genes crucial for vision were multiplied in the early stages of vertebrate evolution and acquired distinct functions leading to the sophisticated mechanisms of vertebrate eyes. One striking feature of vertebrates is the prominent role that vision plays in almost all major animal groups. […]
Olli Kallioniemi new Director for SciLifeLab
The board of SciLifeLab has appointed Professor Olli Kallioniemi as new Director from July 1, 2015. Professor Kallioniemi will be in full service from September 2015. He will present his research at SciLifeLab Day on April 29 in Aula Medica at Karolinska Institutet, Solna.
SciLife Innovation Get Together
On March 24 SciLifeLab organized a meet up for the SciLife Innovation projects at Navet in Uppsala. The meeting began with a presentation about SciLifeLab by Karin Forsberg Nilsson, Scientific Director at SciLifeLab, followed by an overview of SciLife Innovation by Bo-Ragnar Tolf, head of Karolinska Institutet Innovation office. Both researchers and company representatives then […]
Mass-cytometry facility availble for researchers all over Sweden
SciLifeLab’s facility for mass-cytometry (CyTOF) is now part of the national infrastructure and therefor available for applications by the entire Swedish research community.
Unique tooth reveals details of the Peking Man’s life
In 2011 a tooth from the Peking Man was found in a box at the Museum of Evolution at Uppsala University. In the latest issue of Acta Anthropologica Sinica, researchers at SciLifeLab/Uppsala University and a Chinese research institute have now published their analysis of the tooth. The discovery gives us new knowledge about one of […]
New call for national projects
SciLifeLab welcomes applications for the second call of the Swedish Genomes and Biodiversity programs. The projects focus on two areas: human whole genome sequencing to study the genetic basis of disease, and biodiversity.
How blood group O protects against malaria
In a study published in Nature Medicine, a team of Scandinavian scientists explains the mechanisms behind the protection against malaria that blood type O provides. The study also suggest that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population. Among the researchers behind […]
SciLifeLab at SciFest
SciLifeLab will participate at SciFest 2015 with four activities to encourage children’s interest in science. The topics include finding cancer cells, hand hygiene, zebrafish embryos and DNA code. SciFest is a science festival organized by Uppsala University (TekNat-samverkan), Destination Uppsala, Teknik College, Uppsala Kommun, Länsstyrelsen and Regionförbundet during March 19-21. The first two days are dedicated […]
Gene for arsenic tolerance has been discovered
A new study from Uppsala University and Karolinska Institutet shows that some indigenous groups in the Andes, northern Argentina, has increased their resistance to arsenic. Researchers have also found the gene that underlie the altered metabolism that protects against arsenic. Mattias Jakobsson at SciLifeLab and Uppsala University is one of the researchers behind this study. […]
Change of chair
Today Aristidis Moustakas, who has been chair for SciLifeLab The Svedberg Seminar series for 15 years, was thanked for his long commitment to the seminar series. This seminar series has a history from the middle of the 70s and has been reshaped and renamed during the years. It got its curent name in spring 2013. […]
Articles in high impact journals
SciLifeLab frequently contributes to articles published in high impact journals by providing facility services to research groups. For example; three articles to which the SNP&SEQ technology platform in Uppsala has contributed to were published online in Nature on February 11. Two of them were also published in the printed issue on February 12.
The genetics of obesity is mapped
An international team of researchers has identified 89 new genetic loci linked to obesity. Several functions in the central nervous system appears to play an important role in the development of obesity, as well as the metabolism of adipose tissue and insulin. One of the researchers who has lead the study is Erik Ingelsson at […]
Evolution of Darwin’s finches and their beaks
A team of scientists from Uppsala University and Princeton University, led by Leif Andersson at SciLifeLab in Uppsala, has now shed light on the evolutionary history of Darwin’s finches and have identified a gene that explains variation in beak shape within and among species. The study was published in Nature, on the day before the […]
Time to apply for bioinformatics support
Bioinformatics Long-term Support (WABI) at SciLifeLab offers support in next generation sequencing. The idea is simple: A senior bioinformatician will work in your project 500 hours for free! Deadline for the next round of applications to be reviewed by the national evaluation committee is Friday February 27. Applications form projects anywhere in Sweden are welcome.
Meeting with the SciLifeLab Scientific Advisory Board
On February 2-3, the SciLifeLab Scientific Advisory Board (SAB) made a visit to Stockholm and Uppsala.
U.S. Ambassador visits SciLifeLab
Today U.S. Ambassador Mark Brzezinski visited SciLifeLab in Uppsala. Kerstin Lindblad-Toh, Co-Director of SciLifeLab, presented the SciLifeLab mission as well as the center’s high profile science and impact on society. Participating scientific directors described SciLifeLab initiatives within innovation, drug development and environment. The Ambassador was also given a guided tour at the sequencing facilities. He […]
SciLifeLab sets up Swedish national center for single-cell biology
Three new facilities for single cell biology are being set up at SciLifeLab in Stockholm and Uppsala during spring 2015. The new facilities will render technological advances in Sweden and abroad widely available to the Swedish scientific community, with the goal for the region to become world leading in advanced molecular single cell analyses. Advances […]
Genetic variation in children’s tumors leads the way to better treatment
More and more children with cancer survive today – but it is still 10-20 percent of adolescent patients who die in their illness. A team of researchers have found a new way to separate out the most malignant tumors, so that they can be given a more powerful treatment. The study was led by researchers at Lund University. Researchers from the SciLifeLab Array and Analysis Facility in Uppsala has designed and performed the bioinformatic analyzes.
A gene that causes late fetal death have been identified
Researchers at SciLifeLab, Uppsala University and Uppsala University Hospital have identified a new gene that can cause stillbirth in a late stage of the pregnancy. The results can be used to help families to diagnose a child who has died and also for prenatal diagnosis. The study was published today in the Journal of Medical Genetics. […]
First major analysis of Human Protein Atlas published in Science
A research article published in Science presents the first major analysis based on the Human Protein Atlas. The study includes a detailed picture of the proteins that are linked to cancer, the number of proteins present in the bloodstream, and the targets for all approved drugs on the market.
Environment drives human immune variation more than genes
A study of twins led by Petter Brodin, Karolinska Institutet/SciLifeLab, shows that our environment, not our heredity, plays the starring role in determining the state of our immune system, the body’s primary defense against disease.
New insights into protein secretion through cell membranes
For the first time ever scientist have succeeded in measuring the electric force that influence charged amino acids in a protein when the protein chain passes through the cell membrane of a bacteria. The study, led by Gunnar von Heijne at Stockholm University/SciLifeLab, was published in Nature Structural and Molecular Biology.
How host-virus coevolution unmasked from the genomic record
Retroviruses are important pathogens, which have attacked vertebrate hosts for millions of years. Researchers at SciLifeLab now provide new knowledge about the long-term interactions of retroviruses and their hosts by analyzing endogenous retroviruses (ERVs), retroviruses whose genes have become part of the host organism’s genome. The findings are being published in Proceedings of the National Academy of Sciences, PNAS.