Workshop on Enhancing Cross-Platform Collaboration in Integrative Structural Biology
October 21, 2025 @ 12:00 – October 22, 2025 @ 15:30 CEST
Integrative Structural Biology (ISB) is a rapidly advancing field that relies on the integration of diverse datasets, such as those from Cryo-electron microscopy, X-ray crystallography, NMR, Mass spectrometry and Modeling. By integrating different structural techniques we can solve the structure of challenging biological systems, which wouldn’t be possible using a single type of data. However, the current landscape is fragmented, with significant challenges in data interoperability, tool integration, and cross-disciplinary collaboration. The primary objective of this workshop is to foster cross-platform collaboration by bringing together key stakeholders from experimental and computational platforms.
The workshop aims: To facilitate the exchange of ideas and experiences, define the technical and scientific requirements for an Integrative Structural Biology Portal and engage with experts in multimodal data analysis.
This event is organized by SciLifeLab Lund and the Integrated Structural Biology Platform.
Scientific Committee:
Cecilia Persson, University of Gothenburg
Esko Oksanen, Lund University/ESS
Nicholas Pearce, Linköping University
Wolfgang Knecht, Lund University
Wojtek Potrzebowski, SciLifeLab Lund
Local Organizing Committee:
Wojtek Potrzebowski, SciLifeLab Lund
Anabella Aguilera, SciLifeLab Lund
Sophie Hellstrand, SciLifeLab Lund
Schedule
Day 1
- 12:00 – 13:00 Registration & Lunch
- 13:00 – 13:10 Welcome
- 13:10 – 13:55 Keynote Harald Schwalbe, Johann Wolfgang Goethe-University, Frankfurt, “The future of integrated structural biology – selected examples from the European Integrated Infrastructure: Instruct-ERIC”
- 13:55 – 14:15 Giulio Tesei, Malmö University, “Data-driven modeling of intrinsically disordered and multi-domain proteins”
- 14:15 – 14:30 Nabanita Mandal, Lund University, “Unraveling the Conformational Landscape of Amyloid Precursor Protein Intracellular Domain”
- 14:30 – 15:00 Coffee Break
- 15:00 – 15:45 Keynote: Max Bonomi, Institut Pasteur, France, “Probabilistic approaches for integrative structural biology”
- 15:45 – 16:15 Ingemar André, Lund University, “How to optimally combine experimental data with molecular modeling to describe the structure of complex protein mixtures in solution”
- 16:15 – 16:30 Malin Bäckström, University of Gothenburg, “Protein Production Sweden – a national research infrastructure for protein production”
- 16:30 – 17:15 Bridging the Gaps: Tackling Real-World Challenges in Integrative Structural Biology. (A panel discussion on supporting users in navigating experimental design, data integration, and reproducibility in integrative structural biology)
- 17:15 – 17:30 Javier Fernandez Collado, ThermoFisher Scientific, “High throughput, high resolution: Pushing the limits of structure determination with Cryo-TEMs and SmartEPU”
- 17:30 – 19:30 Workshop Mingle
Day 2
- 08:45 – 09:00 Coffee
- 09:00 – 09:40 Björn Forsberg, Linköping University, “Tools and perspectives for cryo-EM processing to answer biological questions”
- 09:40 – 10:10 Mikael Akke, Lund University, “Resolving Protein–Ligand Binding Pathways by NMR Relaxation”
- 10:10 – 10:30 Coffee Break
- 11:15 – 11:35 Nandan Haloi, KTH, “Protein dynamics in the data-driven era”
- 11:35 – 11:50 Carl G. Henning Hansen, University of Copenhagen, “A Bayesian approach to interpret time-resolved experiments using molecular simulations”
- 11:50 – 12:20 Pablo Villanueva-Perez, Lund University, “AI for 3D and 4D (3D+time) inverse problems”
- 12:20 – 13:15 Lunch
- 13:15 – 13:45 Claudio Mirabello, Linköping University, “Integration of experimental restraints in protein structure predictions with AlphaFold”
- 13:45 – 14:30 Panel Discussion: Multi-Modal AI: The Next Frontier in Structural Biology?
- 14:30 – 15:00 Final Plenary: Strategic Roadmap for Future Collaboration
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