BiG Talk – Best practices and common pitfalls in methylome sequencing analysis
Abstract Whole-genome methylation sequencing provides single-base resolution of DNA methylation but remains one of the most computationally challenging omics data types to process. Its complexity stems from bisulfite-induced sequence conversion, protocol-specific artifacts, and the large number of available software tools, making reproducible analysis and cross-study integration particularly difficult. To address this we systematically benchmarked ten […]
