Infrastructure update: The Integrated Structural Biology platform (ISB)

The new ISB platform includes The Swedish NMR Centre and the Structural Proteomics Units and is virtually linked to the SciLifeLab CryoEM unit. The platform coordinates the service area together with stakeholders such as  MAX IV, ESS, PPS and ProLinC. This means that users will soon be able to reach all structural biology technologies from a single access point at the SciLifeLab web. Together with the InfraLife project and SciLifeLab offices in Lund, Gothenburg and Umeå, the ISB platform extends the national scope of SciLifeLab.  

“The new ISB platform brings together the latest development and state-of-the-art technology, making advanced structural protein analysis broadly accessible”, says platform director Göran Karlsson (GU/Swedish NMR Centre). 

The Structural proteomics unit in Lund, has recently acquired a new Orbitrap Eclipse Tribrid mass spectrometer, that provides several exciting advances for state of the art analysis of protein interactions and conformational dynamics of proteins in native conditions. This is achieved by hydrogen-deuterium exchange mass spectrometry (HDX-MS), Crosslinking (XL)-MS and affinity-purification (AP)-MS. 

NMR (Gothenburg and Umeå) takes sensitivity and reduced sample size to new levels in NMR-based structural biology through the 3mm 900 MHz cryoprobe for solution NMR and the 0.7 mm 850 MHz UF-MAS probe for solids and membrane proteins NMR.”