Drug Discovery Seminars: An adaptable Drug Affinity Conjugate (ADAC) targeting CD40
Proof of Concept and Pharmaceutical profiling Sara Mangsbo, Uppsala University Abstract: Much attention has focused on developing CD40 directed agonistic monoclonal antibody therapy. Monoclonal antibodies targeting CD40 have been profiled for their epitope specificity and isotype in relation to their agonistic potential. Still, clinical impact relies on a well-balanced clinical efficacy versus target-mediated toxicity. As CD40-mediated […]
CryoEM in Drug Discovery
Session 1 All time slots below are in UTC+2 / CEST Time zone . June 8th – Afternoon 14:00Welcome wordsAnnika Jenmalm-Jensen, Infrastructure Director, SciLifeLab14:05Introduction to the cryo-EM Unit at SciLifelabMarta Carroni, SciLifeLab/Stockholm University, Sweden14:15From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development Corey Strickland; Merck, Kenilworth, United States14:55CryoEM at AstraZenecaChris Phillips; Astra […]
[Drug Discovery Seminars] Targeting the oncogenic TGFβ signaling pathway in cancer to inhibit invasion and metastasis
Maréne Landström October 28, 13:00-14:00 Welcome to join this Drug Discovery Seminar hosted by the Drug Discovery and Development Platform. Presenter: Professor Maréne Landström, M.D., PhD Dept. Medical Biosciences, Umeå University Maréne Landström is a professor in Pathology at Department of Medical Biosciences, Umeå University, Sweden. She has made her postdoctoral training at the Ludwig Institute of Cancer Research, […]
[Drug Discovery Seminar] How protein degradation led to faculty entrepreneurship at Yale: A personal Perspective
SciLifeLab Drug Discovery Seminars, hosted by the DDD platform, is a series of educational lectures about recent developments, technologies, and trends in drug discovery and development that aims to enlighten, and spark a discussion, within the Swedish drug discovery community. Craig Crews John C. Malone Professor of Molecular, Cellular, and Developmental Biology and Professor of […]
[Drug Discovery Seminar] PROTAC Degraders: From Fundamental Chemical Biology to Translation and Entrepreneurship
SciLifeLab Drug Discovery Seminars, hosted by the DDD platform, is a series of educational lectures about recent developments, technologies, and trends in drug discovery and development that aims to enlighten, and spark a discussion, within the Swedish drug discovery community. Alessio Ciulli Professor of Chemical Structural Biology Centre for Targeted Protein Degradation, School of Life […]
SciLifeLab Drug Discovery Seminar & DDD Exit event: Thomas Helleday
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress Professor Thomas Helleday, Karolinska Institutet SciLifeLab Drug Discovery Seminars, hosted by the DDD platform, is a series of educational lectures about recent developments, technologies, and trends in drug discovery and development that aims to enlighten, and spark a discussion, within […]
11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development
Uppsala University’s Department of Pharmacy hosts the 11th Pharmaceutical Profiling meeting on Thursday, January 27, 2022, at The Humanities Theatre, English Park Campus, Uppsala. January 27, 2022The Humanities Theatre, English Park Campus, UppsalaConfirmed speakers Kathryn A. Whitehead (Carnegie Mellon University, US)Ola Engkvist (AstraZeneca, Sweden)Carolina Wählby (Uppsala University, Sweden)Samir EL Andaloussi (Karolinska Institutet, Sweden)Ola Spjuth (Uppsala […]
Information Meeting: Call for therapeutic oligonucleotide projects
This digital information meeting will be held April 4, 2022 at 14.00–15.00. At this meeting, there will be a presentation of the call and you as an applicant will have the opportunity to ask questions about the call and the application process. The mission of the Drug Discovery and Development Platform at SciLifeLab is to […]
New developments in upstream bioprocessing technologies seminar
Presentation och demonstration av nya single use bioreactors (SUB) för mammalieceller. Program: 9:30-10:15 Matthijs Neimeijer, Cultivating red blood cells in singe-use bioreactors 10:15-10:45 Fika och demonstration 10:45-11:30 Michel Kensler, Comparisons in scale up and down scale 11:30-12:00 Questions
A novel, antibody-based radiopharmaceutical for advanced thyroid cancer
Presenter: Dr Marika Nestor, Department of Immunology, genetics and pathology, Uppsala University, Sweden Molecular radiotherapy is increasingly becoming a powerhouse in the field of cancer- and radiation therapy. By targeting a structure that is abundant on tumor cells but scarce in healthy tissues, a cancer-targeting molecule labeled with a therapeutic radionuclide can mediate the delivery […]
Call for new drug discovery projects – New SciLifeLab Capability for DNA encoded chemical libraries
Call for new drug discovery projects to SciLifeLab DDD for the fall 2022 and introduction of a SciLifeLab capability for DNA encoded chemical librari
Calls for new project support in chemical biology and drug discovery
The chemical biology unit (CBCS) and the Drug discovery and development (DDD) platform at SciLifeLab have calls out for projects. CBCS is looking for projects in Chemical Biology which includes assay development for small molecule screening and profiling, as well as enabling chemistry. For more information, please visit www.cbcs.se. The DDD platform has a call […]