Technology Development Projects (TDPs)

The projects in the list below have been approved by the SciLifeLab board to receive TDP funding. Part of the funding came from the national SciLifeLab infrastructure funding, while most of it was contributed by the Strategic SciLifeLab funding (SFO) received by the four host universities KTH, KI, SU and UU.

Annika Jenmalm Jensen, Infrastructure Director of SciLifeLab, explains the importance for SciLifeLab to support technology development and explore new technologies that could enable breakthrough discoveries to be made in the future

“The purpose of the TDPs is to help SciLifeLab national infrastructure units to offer improved and new services and to keep the SciLifeLab infrastructure at the cutting-edge.”

Annika Jenmalm Jensen, Infrastructure Director at SciLifeLab.

Stories

SciLifeLab´s Ancient DNA Unit: Unlocking the Secrets of Plant Evolution and Ecosystems with unique DNA Analysis tools

SciLifeLab Uppsala unit develops unique long-read DNA sequencing towards clinical practice

Morphological profiling for compound profiling and drug discovery on the SciLifeLab table

Approved Technology Development Projects 2021-2023

Click on title to view a poster describing the project.

Main Applicant	Title
Björn Nystedt, Uppsala University	BeyondFold – Advancing structural biology with deep-learning approaches
Bengt Persson, Uppsala University	AI-enabled virtual screening for chemical probes
Magnus Lundgren, Uppsala University	Analysis of ancient and herbarium plant DNA
Amanda Raine, Uppsala University	Ultra-pooled SPLAT-seq (upSPLAT-seq) a method for cost-effective, large-scale pooled sequencing library preparation applicable to diverse sample types
Adam Ameur, Uppsala University	Targeted long-read sequencing and epigenetic profiling
Pär G. Larsson, Umeå University	NGS-based telomere analysis
Bernhard Schmierer, Karolinska Institutet	Enabling high-content phenotyping in pooled CRISPR screens by in situ sgRNA readout
Maria Pernemalm, Karolinska Institutet	Unique cross platform plasma proteome capability combining mass spectrometry and affinity proteomics
Hans Stenlund, Umeå University	A Modular Bioinformatics Pipeline for high throughput metabolomics at the SciLifeLab Metabolomics Platform
Xiaoze Li Wang and Charlotte Stadler, KTH	DRP-CODEX: Establishing simultaneous detection of DNA, RNA, and proteins on the CODEX platform
Charlotte Stadler, KTH	Bringing multiplexed immunofluorescence to clinical practice – a proof of concept study
Rebecca Howard, KTH	A Pipeline for Tissue Clearing and Expansion
Marianna Tampere, Karolinska Institutet	Improved understanding of drug mechanism-of-action by establishing a nation-wide service of morphological profiling

Approved Technology Development Projects 2019-2020

High-throughput screening in live zebrafish
Bifunctional Protein Degrader (BIPOD) – Towards tissue selective PROTAC’s
Eukaryotic protein production for biomedical research
Mass Spectrometry Imaging in Neuroscience (Neuro-MSI)
MF-SIM: Live Cell Super-Resolution 4D-Microscopy
High -dimensional secretomic analysis of single cells for systems-level immunomonitoring
Production of proteins and glycoproteins in mammalian cells
Ultra-sensitive monitoring of tumor DNA in plasma from cancer patients
Novel method for identifying the effect of DNA sequence variants on common diseases
Multiplexed imaging tools for high-dimensional protein maps of human cells and tissues
Spatial Genomics
Deep and quantitative phosphoproteomic profiling of biological samples
RIF-Seq: RNA isolation free RNA sequencing
CRISPR Screening 2.0
Improved drug discovery using single-cell resolution target-engagement profiling
Artificial Intelligence and Image Analysis for Whole Slide Imaging (AIIA-WSI)