[The Svedberg seminar] – Engineered Salmonella for drug delivery to solid tumors
December 8 @ 15:15 – 16:15 CET
Professor of Chemical Engineering
University of Massachusetts, USA
Neil Forbes is a Professor of Chemical Engineering at the University of Massachusetts, Amherst. He is an adjunct member of the Molecular and Cell Biology Program and a member of the Institute for Applied Life Sciences. He received a BS in Chemical Engineering from Case Western Reserve University, received a PhD in Chemical Engineering from the University of California at Berkeley (with Harvey Blanch and Douglas Clark), and was a postdoctoral fellow (with Rakesh Jain) in Radiation Oncology at Harvard Medical School / Massachusetts General Hospital.
Engineered Salmonella for drug delivery to solid tumors
Abstract: Engineered bacteria have the potential to overcome the limitations that cause cancer therapies to fail. We have created intracellular delivering Salmonella that accumulate in tumors over healthy tissue and deposit deliver therapeutic payloads directly into the cytoplasm of cancer cells. Bacterial delivery of constitutively active caspase-3 blocks the growth of hepatocellular carcinoma and lung metastases, and increases survival in mice. Salmonella delivery of an exogenous antigen, such as from a childhood vaccine, marks cancer cells as foreign, and triggers a cytotoxic, antigen-specific CD8 T cell responses. In mice, intracellular antigen delivery clears established pancreatic tumors, increases survival, and prevents tumor re-implantation by establishing new immunity to intrinsic tumor antigens. This tunable platform could deliver an array of protein drugs to target many hard-to-treat intracellular pathways. As an off-the-shelf therapy, these bacteria are not dependent on intrinsic tumor characteristics and would be effective for a broad range of cancer patients.
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