Policing secretion: cargo capture into ER-derived vesicles initiates secretion
February 21, 2025 @ 10:00 – 11:00 CET
Visiting Professor Liz Miller from the Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Scotland UK, will give a seminar at SciLifeLab Campus Solna. The seminar should be of particular interest to cell and structural biologists interested in membrane associated processes operating during the early stages of the secretory pathway.
Background
One third of the proteins encoded in eukaryotic genomes pass through the secretory pathway, entering via the endoplasmic reticulum (ER). The Miller lab has made pivotal contributions, dissecting the molecular mechanisms operating during the early stages of ER-associated secretory protein biogenesis. Specifically, the research has focused on understanding protein quality control and export from the ER. The lab has exploited the budding yeast, Saccharomyces cerevisiae, as a model system, taking advantage of the full spectrum of biochemical, genetic, genomic and proteomic tools, including cryo-EM. The research has defined mechanisms relevant to a number of human diseases, most notably cystic fibrosis and similar diseases of protein misfolding. Recently, the Miller lab has been examining how secretory cargo is selected for ER export in human cells, which will be the focus of her talk here at SciLifeLab Campus Solna.
Biography
Professor Liz Miller carried out her PhD in Melbourne, Australia, working on intracellular traffic of plant defence proteins. In 1999, as a Jane Coffin Childs Postdoctoral Fellow, she joined Randy Schekman’s lab (note: prior to his Nobel Prize awarded in 2013) at the University of California, Berkeley. In the Schekman lab, Liz established the mechanistic basis for capture of nascent secretory proteins into ER-derived COPII vesicles. In 2005 Liz established her independent lab at Columbia University in New York, and after 10 years moved to become a Programme Leader/MRC Investigator at the MRC Laboratory of Molecular Biology in Cambridge, where she maintains a small lab. In 2023, Liz joined the Division of Molecular, Cell and Developmental Biology within the School of Life Sciences in 2023.
Host: Per Ljungdahl, per.ljungdahl@scilifelab.se
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