Precision phenotyping in dilated cardiomyopathy
March 21, 2025 @ 09:00 – 09:40 CET
Charlotta Ljungman, Senior consultant
This Clinical talks has been rescheduled – from February 28 to March 21. Any prior registrations remains valid.
Charlotta Ljungman is senior consultant and associate professor in cardiology working at Sahlgrenska University Gothenburg.
Her research involves aspects of heart failure and cardiomyopathy and she is the founder of Sahlgrenska Cardiomyopathy Center. She is also the chair of the Swedish heart failure registry (Swede-HF)
Abstract
Precision phenotyping has been suggested to find new subtypes and biomarkers in heart failure and dilated cardiomyopathy (DCM), the most common cardiomyopathy, and were the cause in 50% of the cases is unknown. Therefore, the aim of this project is to combine proteomics and metabolomics to:
- Understand cardiac energy metabolism in heart failure and DCM.
- Find subtypes and biomarkers by multimodal precision phenotyping with proteomics and integration of data
Once established, the precision phenotyping approach may allow identification of patients/subtypes at greatest risk, find new biomarkers and allow intervention and personalized follow-up of high-risk individuals.
The aim will be achieved by investigating cardiac energy metabolism (uptake and release) and proteomic profile in relation to cardiac function at rest and during exercise, in patients in comparison to healthy controls. Patients undergoing right heart catheterization (RHC) with the diagnosis of heart failure and DCM without metabolic disease are included in a prospective mechanistic case control study of cardiac energetics; the MEtabolic CHAracterization of patients with Dilated cardiomyopathy (MECHAD) study. Age and sex matched controls without heart failure undergoing electrophysiological examination are included. Arterial blood supply tissues and organs with oxygen and metabolites for energy and venous blood carry the metabolic by-products and carbon oxide from tissues and organs. This allows to calculate uptake and release of metabolites and oxygen through arteriovenous approach by simultaneous sampling in artery (to the heart) and the coronary sinus (from the heart) when performing RHC and calculate cardiac energy metabolism and collect samples for proteomics profiling. Patients undergo clinical examinations including medical history, alcohol use disorders identification test, Kansas City Cardiomyopathy Questionnaire, ECG, blood pressure, Transthoracical echocardiography (TTE) and Cardiopulmonary exercise testing (CPET). All patients are followed for 12 months.
Clinical Talks returns with a new season!
After seven successful seasons and over seventy dedicated speakers, we are excited to continue showcasing the contributions of our diverse clinical, academic, and industry Life Science community. This season will feature ten insightful talks, following our well-established format.
The overarching theme is “How to Achieve Feasible Implementation.” Sessions will be held monthly on Fridays from 09:00 to 09:30 am via Zoom, with occasional exceptions. Each talk will be followed by an engaging Q&A session, moderated by standing host Rikard Fred, alongside a guest moderator with subject matter expertise to enrich the discussion.
In today’s rapidly evolving post-pandemic landscape, it is crucial to explore how academic, clinical, and industry research—combined with technological advancements—can drive practical and sustainable solutions. Join us for an opportunity to gain fresh insights, expand your knowledge, and connect with experts shaping the future of Life Sciences!
Clinical Talks are organized by the SciLifeLab’s Precision Medicine Capability
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