[The Svedberg seminar] – Diversity of left-right asymmetry among animals
December 2, 2024 @ 15:15 – 16:15 CET
Hiroshi Hamada
Professor
National Center for Biological Sciences, Ashoka University, India
Bio
Professor Hiroshi Hamada is a visiting professor at National Center for Biological Sciences in Ashoka University, India. Professor Hamada received his M.D from Okayama University in 1975 and his PhD from the same university in 1979. Since then he has worked at several prestigious institutions such as NIH and RIKEN. He has been an associate editor and part of the editorial board on a number of journals within the medical field.
Diversity of left-right asymmetry among animals
Most of animals exhibit left-right (L-R) asymmetries in internal and/or superficial organs, but they employ different mechanisms for L-R asymmetry, especially for symmetry breaking. Many vertebrates including fish, amphibians and mammals, use motile cilia to generate unidirectional fluid flow at the left-right organizer, for symmetry breaking. Birds and reptiles, however, break L-R symmetry without motile cilia, but its mechanism remains unknown. Invertebrates such as insects and snails employ a variety of different mechanisms. We studied the genetic pathway that establishes L-R asymmetry in the mouse, but we are now investigating how chick embryos establish molecular L-R asymmetry without cilia. Also, we have started to investigate how snail embryos establish L-R asymmetric gene expression. I would like to introduce our current attempts with chick and snail embryos.
Host: Gonzalo Sanchez, UU gonzalo.sanchez@mcb.uu.se
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