Gene mapping and population genetics in humans and domestic animals


Description
Target group: PhD students in the biomedical and animal genetics field

Learning Outcomes
By the end of the course, combining taught and independent learning, students should:
- Have an understanding of the basic theory underlying trait mapping
- Have an appreciation of methods available for mapping of trait/disease genes in humans and animals
- Be able to plan and perform a basic genome-wide association study
(GWAS)
- Be able to evaluate their own and others gene mapping research
- Have an understanding of human and animal population structures and their affect on genes and phenotypes
- Have an understanding of how comparative genetics (humans, domestic animals and model organisms) can be utilized to advance research

Contents
The course is divided into 2 blocks. Block 1: This block will provide an introduction to the methods available for mapping trait/disease genes in humans and animals. The block will include background theory to the principles of linkage and linkage disequilibrium as well as study design, genome-wide and candidate gene association methods. Follow-up and alternative approaches, such as nextgen sequencing, will also briefly be described. Block 2: This block includes a computer practical focusing on GWAS and a literature group project. The aim is to provide the students with an opportunity to apply the methods discussed and to critically evaluate studies in the literature.

Instructions
Lectures, seminars, computer practical and literature project. The course is highly participatory and full attendance by all participants is expected.

Examination
Mandatory and satisfactory participation in lectures, seminars, and practicals. Presentation of project

Literature
Selected articles and handouts

Teaching Staff
Teaching Staff
Malin Melin, Jennifer Meadows, Leif Andersson, Kerstin Lindblad-Toh among others

Contact
Malin Melin:
Malin.Melin@slu.se,
018-471 4525
Cecilia Johansson: Cecilia.M.Johansson@imbim.uu.se

Application deadline January 9

Organizer: SciLifeLab

SciLifeLab