Gene mapping and population genetics in humans and domestic animals
Target group: PhD students in the biomedical and animal genetics field
By the end of the course, combining taught and independent learning, students should: - Have an understanding of the basic theory underlying trait mapping - Have an appreciation of methods available for mapping of trait/disease genes in humans and animals - Be able to plan and perform a basic genome-wide association study (GWAS) - Be able to evaluate their own and others gene mapping research - Have an understanding of human and animal population structures and their affect on genes and phenotypes - Have an understanding of how comparative genetics (humans, domestic animals and model organisms) can be utilized to advance research
The course is divided into 2 blocks. Block 1: This block will provide an introduction to the methods available for mapping trait/disease genes in humans and animals. The block will include background theory to the principles of linkage and linkage disequilibrium as well as study design, genome-wide and candidate gene association methods. Follow-up and alternative approaches, such as nextgen sequencing, will also briefly be described. Block 2: This block includes a computer practical focusing on GWAS and a literature group project. The aim is to provide the students with an opportunity to apply the methods discussed and to critically evaluate studies in the literature.
Lectures, seminars, computer practical and literature project. The course is highly participatory and full attendance by all participants is expected.
Mandatory and satisfactory participation in lectures, seminars, and practicals. Presentation of project
Selected articles and handouts
Teaching Staff Malin Melin, Jennifer Meadows, Leif Andersson, Kerstin Lindblad-Toh among others
Application deadline January 9